传统的健康实践可能促进Nrf2激活,类似于运动
Hubert Kolb1,2, Stephan Martin1,2, Kerstin Kempf1
1West-German Centre of Diabetes and Health, Düsseldorf Catholic Hospital Group, 40591 Düsseldorf, Germany.
International journal of molecular sciences
|December 11, 2025
概括
不同的非药物健康实践,如运动和饮食,触发了适应性细胞反应. 这些做法激活了诸如核因素红色素2相关因子2 (Nrf2) 等途径,增强了抗氧化和抗炎防御.
科学领域:
- 细胞生物学 细胞生物学
- 生理学 生理学 生理学
- 健康科学 卫生科学 卫生科学
背景情况:
- 非药物干预越来越多地被认为具有健康益处.
- 运动会诱导分子适应,包括增强抗氧化和抗炎活性.
- 关键的分子媒介,如核因子红色素2相关因子2 (Nrf2) 参与其中.
研究的目的:
- 探索各种非药物健康实践背后的共同分子机制.
- 为了确定由不同的hormetic刺激激活的常见细胞防御途径.
- 研究Nrf2和其他应激反应途径的作用.
主要方法:
- 审查关于运动生理学和非药物干预的现有文献.
- 对分子信号通路的分析,包括Nrf2,Sirtuin和AMP激活的蛋白激酶.
- 细胞对各种刺激的反应比较,如热,冷,氧气变化和饮食成分.
主要成果:
- 运动可以调节酶和转录因子,促进抗氧化和抗炎作用.
- Nrf2是各种实践中细胞防御反应的中心调解者.
- 其他途径,如NAD+-sirtuin和AMP激活蛋白激酶也被上调.
- 观察到与热/冷暴露,高/低压氧气,杯水,针,热量限制和多消费相似的适应性反应.
结论:
- 多种传统的健康实践可能共享一个共同的hormetic机制.
- 轻微的细胞压力会触发防御反应,增强抗氧化,抗炎和修复活动.
- 这些适应性反应可以通过Nrf2等途径影响全身组织功能.
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