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新兴乳腺癌亚种群:功能异质性超越经典亚型

Amalia Kotsifaki¹, Georgia Kalouda¹, Efthymios Karalexis¹

¹Physiology Laboratory, Medical School, National and Kapodistrian University of Athens, 11527 Athens, Greece.

International journal of molecular sciences

|December 11, 2025

概括

乳腺癌比以前想象的更复杂,发现了新的亚型. 这些新兴的乳腺癌 (BC) 分类提供了更好的预后,并指导了针对性疾病的向治疗.

科学领域:

在瘤学瘤学.
基因组学就是基因组学.
生物标志物生物标志物

背景情况:

乳腺癌 (BC) 被认为是一种异质性疾病,超过了传统的分类,如光线A / B,HER2丰富和三阴性 (TNBC).
新兴的子群体,如HER2低,克劳丁低,BRCA缺乏 (BRCAness) 和精细的TNBC子群 (例如光线AR,基底类免疫变异) 呈现出新的复杂性.
这些新的分类提供了更好的预后洞察力和治疗途径.

研究的目的:

综合审查新出现的乳腺癌亚型,超越经典的分类学.
在定义这些子组时,整合多原子和液体活检生物标志物的证据.
突出这些生物标志物对向治疗的预测价值和瘤微环境 (TME) 的作用.

主要方法:

从基因组,表观遗传和蛋白质组分析中整合证据.
分析与免疫相关的生物标志物和液体活检数据.
对研究瘤微环境 (TME) 和瘤内异质性的研究进行审查.

主要成果:

新的乳腺癌分类,包括HER2-low,claudin-low,BRCAness和精细的TNBC子集,提供了更大的生物分辨率.
这些新出现的亚型与不同的预后有关,并预测针对性治疗的反应,如抗体-药物合物,PARP抑制剂和免疫检查点抑制剂.
瘤微环境 (TME) 和内异质性显著影响这些新兴乳腺癌实体的生物学和临床行为.

结论:

识别新出现的乳腺癌亚型代表了向动态,生物标志物驱动的精确瘤学转变的范式.
这些在临床上可行的群体使得更好的患者分层和更精细的预后,积极的乳腺癌.
从静态受体模型转向动态,生物标志物驱动的框架对于推进乳腺癌治疗至关重要.

关键词:

这就是BRCAness的意义.在HER2-低的水平下.乳腺癌的亚型乳腺癌的亚型克劳丁-低的时间新兴的人口新兴的人口.功能异质性的功能异质性内异质性的异质性精确瘤学精确瘤学预后生物标志物预后生物标志物瘤微环境是一个微环境.

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