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腺病毒载体相关静脉血栓的红细胞相关特征

Hanjin Park¹, Ok-Nam Bae¹, Sungbin Choi¹

¹College of Pharmacy, Institute of Pharmaceutical Science and Technology, Hanyang University, Ansan 15588, Republic of Korea.

International journal of molecular sciences

|December 11, 2025

概括

腺病毒载体疫苗可能会通过影响红细胞 (RBC) 来增加静脉血栓形成的风险. 这项研究表明,腺病毒暴露可以使红细胞更容易凝血,这可能解释了观察到的风险.

科学领域:

免疫学免疫学免疫学
血液学血液学血液学
疫苗学疫苗学疫苗学

背景情况:

腺病毒载体疫苗对于控制传染病,包括COVID-19至关重要.
营销后监测显示,与这些疫苗相关的静脉主导血栓事件.
目前对疫苗诱导的血栓形成的理解往往集中在以血小板为中心的机制上,并没有探索其他因素.

研究的目的:

为了调查红细胞 (RBC) 相关的假设,用于腺病毒载体疫苗诱导的静脉血栓形成.
在临床前模型中评估红细胞在腺病毒暴露后的红细胞的前凝潜力.

主要方法:

使用Ad5向量-rAd/HA(PR8) 的老鼠模型在亚溶解剂量范围内.
通过扫描电子显微镜对脂胺素 (PS) 暴露,形态变化和微粒细胞生成进行了ex vivo评估.
在下静脉模型中量化体内血栓生成和血栓形成.

主要成果:

腺病毒暴露诱导了红细胞表面PS暴露,形状重塑和微囊细胞释放,表明增强了前凝性活性.
暴露后观察到红细胞血栓生成的剂量依赖性增加.
在体内血栓形成模型中,血栓负担的剂量响应性增加,与增强的红细胞血栓性相关.

结论:

实验数据支持红细胞在腺病毒载体相关静脉血栓形成中的作用.
这些发现提供了一个生物学上可信的机制,将腺病毒暴露与观察到的静脉主导血栓流行病学联系起来.
建议在临床前和临床评估中纳入以红细胞为重点的安全终点,以减轻血栓风险.

关键词:

红血细胞的形状改变,改变了形状.腺病毒载体疫苗疫苗腺病毒5型 (Ad5) 病毒红细胞是血液中的红细胞.产生血栓的发生.静脉血栓的形成静脉血栓的形成

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