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Updated: Jan 9, 2026

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在健康和疾病中,内皮细胞转换为介质细胞:分子洞察力和治疗影响

Ran Kim¹, Woochul Chang^1,2

¹Department of Biology Education, College of Education, Pusan National University, Busan 46241, Republic of Korea.

International journal of molecular sciences

|December 11, 2025

概括

内皮转介质转换 (EndMT) 通过改变细胞身份来驱动器官纤维化和癌症. 针对其复杂的途径为纤维化疾病提供了新的治疗策略.

科学领域:

细胞生物学细胞生物学
病理学病理学病理学
翻译医学是一种翻译医学.

背景情况:

内皮转介质转换 (EndMT) 是一个细胞过程,涉及纤维化,血管重塑和癌症.
EndMT有助于各种器官的疾病发病,包括心脏,肺部,脏,肝脏和中枢神经系统.

研究的目的:

合成驱动EndMT的机械路径,包括TGF-β/SMAD,非正规信号,Notch和Wnt/β-catenin级联.
审查针对EndMT的当前和新兴治疗策略.
为分层EndMT状态和开发组合疗法提出一个翻译路线图.

主要方法:

对参与EndMT的机制性途径的审查.
综合有关EndMT发挥作用的疾病背景的信息.
针对EndMT的治疗干预措施的汇编.
讨论先进的平台,如iPSC/organoids和器官在芯片上的研究.

主要成果:

确定了关键的信号级联 (TGF-β/SMAD,MAPK,PI3K/AKT,Rho/ROCK,Notch,Wnt/β-catenin) 和它们与低氧,炎症和表观遗传学之间的交叉声调在驱动EndMT.
记录了EndMT在各种器官系统和癌症中的上下文依赖作用.
列出了广泛的治疗方法,从途径抑制剂到基于细胞和基因的干预措施.

结论:

在纤维性疾病和癌症中,EndMT是一个关键的细胞程序,由复杂的信号网络驱动.
多方面的治疗策略,包括针对多个途径,表观遗传学和免疫系统的组合疗法,对于有效的治疗至关重要.
先进的翻译平台对于分层EndMT状态和优先考虑治疗点至关重要,以实现抗纤维性益处,同时保持生理功能.

关键词:

在TGF-β/SMAD信号传输中.内皮质功能障碍在内皮质功能障碍内皮细胞到介质细胞的过渡.翻译疗法是一种翻译疗法.血管改造血管改造血管改造

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