怀孕期间的维生素D缺乏与产后抑郁症有关:巴西南部的一组研究
Luis Otávio Lobo Centeno1, Aline Longoni1, Jéssica Puchalski Trettim1
1Graduate Program in Health and Behavior, Center of Health Sciences, Laboratory of Clinical Neurosciences, Catholic University of Pelotas (UCPel), Pelotas 96015-560, RS, Brazil.
怀孕期间维生素D (25-基维生素D) 水平较低,与产后抑郁症的风险增加了一倍. 监测维生素D对于母亲的心理健康至关重要.
科学领域:
- 产科和妇科 产科和妇科
- 孕产妇心理健康 孕产妇心理健康
- 营养科学 营养科学
背景情况:
- 产后抑郁症 (PPD) 显著影响母亲和婴儿的福祉.
- 维生素D (25(OH) D) 可能影响情绪调节,但证据是相互矛盾的.
- 孕期维生素D缺乏是PPD的潜在危险因素.
研究的目的:
- 调查怀孕期间维生素D缺乏与PPD诊断之间的关联.
- 为了确定低血清维生素D水平是否会增加患PPD的可能性.
主要方法:
- 在巴西佩洛塔斯 (Pelotas) 长度研究了713个母子双.
- 血清维生素D水平通过化学发光测量到24周怀孕.
- 使用迷你国际神经精神病学面试 (M.I.N.I.I.I.I.M.I.N.I.I.I.I.I.I.I.I.) 诊断的PPD. 加);逻辑回归调整为混因素.
主要成果:
- 孕期维生素D缺乏 (≤19.9μg/mL) 与PPD风险增加两倍有关.
- 缺陷与非缺陷组中PPD的调整几率比率 (OR) 为2.0 (95%CI为1.0-4.2;p=0.049).
结论:
- 怀孕期间维生素D缺乏是产后抑郁症的重要危险因素.
- 在产前护理中监测和确保足够的维生素D水平可能有助于减少PPD发病率.
- 研究结果强调了维生素D对母亲心理健康的重要性.
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