通过血清和的比率来评估的状态
Andrea Rosanoff1, Bodo von Ehrlich2, Deanna Nelson3
1CMER Center for Magnesium Education & Research, Pahoa, HI 96778, USA.
Nutrients
|December 11, 2025
概括
使用血清 (Mg) 和 (Ca) 比率的新尺度,与单独使用血清相比,为Mg状态提供了更好的诊断价值. 这种尺度显示出预测死亡率和评估各种患者群体的Mg缺陷的潜力.
科学领域:
- 生物化学 生物化学
- 临床诊断 临床诊断 临床诊断
- 营养科学 营养科学
背景情况:
- 准确评估人体 (Mg) 状态对于临床实践至关重要.
- 目前使用血清Mg和 (Ca) 比率的方法缺乏标准化,采用四个可互换的表达式.
- 需要采用统一的方法,通过血清比率可靠地评估Mg状态.
研究的目的:
- 提出和验证一种统一的尺度来评估人类的状况,使用血清Mg和Ca的比率.
- 在各种临床场景和已发表的研究中探索这种拟议尺度的诊断实用性.
- 为了确定拟议的尺度是否提供优越的诊断价值相比单独的血清Mg.
主要方法:
- 开发一种统一的血清Mg/Ca和Ca/Mg比率尺度,适用于重量和摩尔数计算.
- 将拟议规模应用于四个案例研究.
- 分析已发表的研究数据,包括COVID-19死亡率,健康成年人,牙周病和急性冠状动脉综合征患者.
主要成果:
- 在案例研究中,拟议的血清Mg/Ca量表显示出高于单独的血清Mg的Mg诊断价值.
- 在住院COVID-19患者中,尺度的"耗尽Mg"状态预测了死亡率.
- 对健康成年人的分析显示,即使有"正常"血清Mg,Mg状态也存在很大范围 (从"严重耗尽"到"充足").
- 该尺度显示了牙周病的预后价值,并确定了当"纠正的Ca"被排除在外时,急性冠状动脉综合征的适当诊断实用性.
结论:
- 拟议的Mg/Ca比率尺度要求在相同的单位 (重量或) 中一致报告血清 Ca和Mg总量.
- 报告单位和血清Mg和Ca比率的方法的标准化对于清晰度至关重要.
- 拟议的尺度需要进一步调查,因为它可能比单独的血清Mg更准确地标志着Mg缺乏.
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