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物理化学性质确定复合人体溶酶及其对小鼠肠道发育的影响

Ruwei Liu¹, Qin An², Yunxia Zou²

¹Department of Food Science and Nutrition, College of Food Science and Nutritional Engineering, China Agricultural University, Beijing 100083, China.

|December 11, 2025

概括

复合人体酶 (rhLYZ) 在促进婴儿肠道健康,增强肠道发育,免疫力和微生物群平衡方面比蛋白酶 (HEWL) 具有更高的疗效.

科学领域:

生物化学生物化学
免疫学免疫学免疫学
微生物学微生物学

背景情况:

母乳酶对于婴儿的肠道健康至关重要.
低的母乳养率需要替代品,如母蛋白溶酶 (HEWL) 婴儿配方奶粉.
HEWL与人类酶的功能差异需要调查.

研究的目的:

系统地比较复合人体酶 (rhLYZ) 和HEWL.的功能疗效.
评估它们作为婴儿配方奶粉补充剂的适用性.

主要方法:

分析了rhLYZ和HEWL的物理化学特性 (酶活性,pH,热稳定性).
在HT-29肠道细胞和小鼠幼模型中评估了生物功能.
利用基因表达的转录组分析,检查肠道微生物群的组成.

主要成果:

rhLYZ表现出更高的酶活性和增强的肠细胞分化.
在体内,rhLYZ改善了幼生长,肠道成熟度和肠道微生物群多样性,表现优于HEWL.
rhLYZ上调了广泛的抗微生物和免疫基因,与HEWL的更狭窄的反应不同.

结论:

rhLYZ有效地模仿人乳溶酶,促进肠道发育,免疫力和平衡的微生物群.
与 rhLYZ.LYZ 相比,HEWL 的功能概况更为有限.
rhLYZ在婴儿配方奶粉补充中具有卓越的潜力.

关键词:

的HT-29细胞.蛋白色的酶溶解剂是什么?肠道的发育肠道的发育物理化学特性物理化学特性再组合的人类溶酶.

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