高强度间歇运动通过招募非伴体细胞来驱动骨肌肉中的维生素D受体表达,而不是通过肌肉纤维的升级调节
Kenneth Ladd Seldeen1,2, Ni Wang1, Rupadevi Muthaiah1
1Division of Geriatrics & Landon Center on Aging, University of Kansas Medical Center, Kansas City, KS 66103, USA.
Nutrients
|December 11, 2025
概括
高强度间歇运动 (HIIE) 在老年小鼠中引起暂时的炎症反应和基因表达变化,维生素D受体 (VDR) 蛋白水平持续更长时间,这表明HIIE有助于老年人肌肉适应和恢复.
科学领域:
- 运动生理学 运动生理学
- 分子生物学分子生物学
- 衰老研究研究 衰老研究
背景情况:
- 高强度间歇运动 (HIIE) 提供比中等强度运动更短的运动方案.
- HIIE诱导显著的肌肉适应,包括代谢重塑和改善耐力.
- 运动对维生素D受体 (VDR) 表达的影响,特别是在HIIE期间,需要进一步研究.
研究的目的:
- 研究单次HIIE对炎症性细胞因子和基因表达 (包括VDR) 在老化骨肌肉中的时间依赖性影响.
- 为了比较老年小鼠在HIIE后1,4小时和24小时的分子变化.
主要方法:
- 对久坐不动的老年小鼠进行了10分钟的HIIE会话.
- 血液和骨肌肉组织在运动后1,4小时和24小时收集.
- 基因和蛋白质表达 (包括VDR) 通过RT-PCR,西斑和免疫组织化学分析.
主要成果:
- HIIE诱导了暂时的全身炎症反应,在运动后4小时达到顶峰.
- 在HIIE后1个小时和4个小时,mRNA配置文件显示出不同的模式,在24小时后恢复到基线.
- VDR蛋白表达在HIIE后24小时持续存在,并与骨肌肉中的卫星细胞和巨细胞同定位.
结论:
- 在24小时内,HIIE会在老化的骨肌中引发短暂的分子变化.
- 持续的VDR蛋白表达表明它在运动诱导的肌肉重塑和恢复中起着作用.
- HIIE显示出增强肌肉适应和恢复的潜力,特别是在老年人中.
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