新诊断的格雷夫斯病患者的身体组成和饮食习惯与甲状腺控制相比
Laura Croce1,2, Cristina Pallavicini2, Vittorio Gabba3,4
1Department of Internal Medicine and Therapeutics, University of Pavia, 27100 Pavia, Italy.
Nutrients
|December 11, 2025
概括
格雷夫斯病 (GD) 患者表现出身体成分的改变,包括水分增加和细胞质量减少. 标准化相角 (SPA) 反映了GD严重程度和营养状况,独立于体重变化.
科学领域:
- 内分泌学 在内分泌学.
- 营养科学 营养科学
- 身体组成分析 身体成分分析
背景情况:
- 格雷夫斯病 (GD) 是甲状腺功能障碍的常见原因,导致身体重量和组成发生显著变化.
- 身体组成变化的临床意义及其与GD中甲状腺功能的联系需要进一步澄清.
研究的目的:
- 根据病前体重变化,评估新诊断的甲状腺过高GD患者的身体组成和饮食习惯.
- 为了将这些参数与年龄,性别和BMI匹配的甲状腺控制对照进行比较.
主要方法:
- 44名GD患者和44名对照人进行了人体测量,甲状腺功能测试和生物电阻分析 (BIA).
- 评估了饮食习惯,使用PREDIMED评分,宏观营养素摄入量和每日总热量摄入量.
- 计算了标准化相角 (SPA) 和体细胞质量指数 (BCMI) 等营养指数.
主要成果:
- 大多数GD患者 (70.3%) 经历了诊断前的体重减轻,但大小与甲状腺毒性病的严重程度没有相关性.
- 与对照组相比,GD患者表现出较低的相角和SPA,更高的细胞外水,以及降低的BCMI.
- SPA与甲状腺激素水平 (FT3,FT4) 和TRAb显著相关,独立于其他因素.
结论:
- 甲状腺功能高的GD患者出现了细胞外水的增加和体细胞质量的减少.
- SPA是评估甲状腺毒性病的营养状况的一个有价值的工具,与GD严重程度相反.
- 在GD中疾病前的体重变化可能反映了增加的热量摄入量,而不是疾病的严重程度.
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