蛋白质热量营养不良与炎症性肠病中的结肠粘膜微生物群变化有关
Hyo-Joon Yang1, Melissa Corson2, Ezinne Aja2,3
1Division of Gastroenterology, Department of Internal Medicine and Gastrointestinal Cancer Center, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul 03181, Republic of Korea.
Nutrients
|December 11, 2025
概括
炎症性肠病 (IBD) 患者的蛋白质热量营养不良 (PCM) 与肠道微生物群的改变有关,特别是益生菌Bifidobacterium longum的减少. 需要进一步的研究来了解微生物群.
科学领域:
- 胃肠病学 胃肠病学
- 微生物学 微生物学
- 营养科学 营养科学
背景情况:
- 蛋白质热量营养不良 (PCM) 在炎症性肠病 (IBD) 患者中很普遍.
- 在IBD中PCM和肠道微生物群之间的特定关系在很大程度上仍未被探索.
研究的目的:
- 为了研究PCM和IBD患者的结肠粘膜微生物群组成之间的关联.
- 在IBD肠道中识别受PCM影响的特定微生物种群.
主要方法:
- 从48名IBD患者 (24名有PCM,24名没有) 收集了结肠粘膜样本.
- PCM被定义为身体质量指数 (BMI) <18.5 kg/m2和/或显著的体重减轻.
- 进行了细菌16S rRNA基因测序 (PacBio Sequel IIe),随后进行了多样性和差异丰度分析.
主要成果:
- 在有或没有PCM的IBD患者之间,没有观察到α或β多样性的显著差异.
- PCM与12种细菌种群的显著变化有关.
- 关键的发现包括肠杆菌 (Intestinibacter bartlettii) 的丰富和Bifidobacterium longum,Sphingomonas leidyi和Clostridium innocuum的枯竭.
结论:
- 患有PCM的IBD患者在他们的结肠粘膜微生物群中表现出明显的变化.
- 在PCM患者中观察到一种已知的益生菌Bifidobacterium longum显著减少.
- 需要进一步的研究来探索PCM中的微生物群在IBD中的作用以及益生菌干预的潜在好处.
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