咖啡因剂量和施用方法对时间试验性能的影响:系统性审查和网络元分析
Ruiguo Xue1, Jin Huang1, Bin Chen2
1School of Athletic Performance, Shanghai University of Sport, Shanghai 200438, China.
Nutrients
|December 11, 2025
概括
低剂量咖啡因囊 (大约3mg/kg) 是最有效的提高耐力赛表现. 适量囊和口香糖也有益,但个人的反应各不相同.
科学领域:
- 运动生理学 运动生理学
- 运动营养 运动营养
- 绩效提升 提高绩效的方法
背景情况:
- 咖啡因是耐力运动员认可的人体工程学辅助剂.
- 对表现的最佳咖啡因摄入策略 (方法和剂量) 尚不清楚.
- 这项研究解决了基于证据的咖啡因补充方案的需求.
研究的目的:
- 系统地审查和网络分析咖啡因的给药方法和剂量,以达到时间试验的性能.
- 为了比较不同咖啡因摄入策略的有效性.
- 为运动员确定最佳的咖啡因补充方案.
主要方法:
- 按照PRISMA指南进行系统审查和网络元分析.
- 在主要的科学数据库中进行全面的文献搜索,直到2025年7月.
- 包括48项研究 (612名参与者) 分析咖啡因 (囊,口香糖,口水) 和剂量 (低:≤3毫克/公斤;中等: 4-6毫克/公斤) 时间试验的表现.
主要成果:
- 低剂量咖啡因囊 (≤3 mg/kg) 显著减少了时间试验完成时间 (SMD = -0.34).
- 中剂量囊 (4-6 mg/kg) 和中剂量口香糖也提高了性能.
- 低剂量囊显示了提高平均输出功率的最高概率 (SMD = 0.38).
结论:
- 低剂量咖啡因囊 (≈3 mg/kg) 是提高计时赛表现的最有效策略.
- 适量囊和口香糖是可行的替代品,但个体反应的变化是显著的.
- 未来的研究应该探索个性化咖啡因补充策略的遗传和身体组成因素.
相关概念视频
Experimental Designs
16.5K
An experimental design is a systematic process that allows researchers to evaluate the relationship between dependent and independent variables. There are three widely used types of experimental design - pre-experimental design, true experimental design, and quasi-experimental design. In pre-experimental design, the researcher compares the data before and after some interventions or treatments. The true-experimental design has more than one purposefully created group, a commonly measured...
16.5K
Chronopharmacokinetics: Circadian Rhythms and Influence on Drug Response
331
Circadian rhythms are cyclic changes that are crucial in plasma drug concentrations. Various standard circadian parameters, including core body temperature, heart rate, and other cardiovascular factors, directly impact disease states and the therapeutic response to drug therapy.
The time of drug administration is an important factor to consider, as it can influence the toxic dose of a drug. For example, a study conducted by Prins et al. in 1997 examined the effects of the timing of...
The time of drug administration is an important factor to consider, as it can influence the toxic dose of a drug. For example, a study conducted by Prins et al. in 1997 examined the effects of the timing of...
331
Cognitive Enhancers: Cholinesterase Inhibitors and NMDA Receptor Antagonists
512
Cognitive enhancers, also known as "smart drugs," are substances used to enhance memory, mental alertness, and concentration. These can be natural or synthetic and improve cognition in conditions like Alzheimer's disease (AD) and other neurodegenerative diseases. Some common examples include caffeine, amphetamines, methylphenidate, modafinil, arecoline, donepezil, vortioxetine, and piracetam. These enhancers work on the principle of synaptic plasticity and altered circuit function.
512
Time Course of Drug Effect
2.6K
The progression of a drug's impact can be analyzed by examining both the concentration-time course and the effect-time course. The concentration-time course is determined by the drug's half-life and is influenced by factors such as its pharmacokinetics, including absorption, distribution, metabolism, and elimination. The effect of the drug is often related to its concentration in the plasma and is calculated using the maximum drug effect and the plasma concentration that generates 50...
2.6K
Bioavailability Study Design: Single Versus Multiple Dose Studies
179
Bioavailability studies are essential for understanding how a drug is absorbed, distributed, metabolized, and excreted in the body. These studies assess the extent and rate at which the active pharmaceutical agent becomes available at the site of action. The design of bioavailability studies can involve single-dose or multiple-dose regimens, each with distinct advantages and limitations.Single-dose studies are the preferred approach due to their simplicity and reduced drug exposure for...
179
Drugs Affecting Neurotransmitter Release or Uptake
1.5K
Certain drugs can affect how neurotransmitters called catecholamines, are released or taken back up in the adrenergic neuron. They can have different effects on the body's sympathetic transmission. Reserpine, a natural compound found in the Rauwolfia shrub, blocks a transporter called vesicular monoamine transporter (VMAT), which leads to a buildup of catecholamines in the cell and reduces sympathetic transmission. Another drug called guanethidine works in multiple ways, including blocking...
1.5K


