菌衍生基托从培养在体外作为一种抗菌矩阵的银纳米颗粒在先进的生物活性材料中
Agata Krakowska1,2, Dominik Műller1, Anna Kula3
1AGH University of Krakow, Faculty of Materials Science and Ceramics, Department of Analytical Chemistry and Biochemistry, Al. Mickiewicza 30, 30-059 Kraków, Poland.
Materials (Basel, Switzerland)
|December 11, 2025
概括
来自Pleurotus ostreatus的真菌奇托显示出强大的抗菌特性. 这种生物活性矩阵,特别是与银纳米颗粒,为生物医学应用提供了增强的抗菌疗效.
科学领域:
- 生物材料科学 生物材料科学
- 菌类学 菌类学是指菌类学.
- 抗菌研究 抗菌研究
背景情况:
- 基托是一种生物聚合物,因其抗菌潜力而受到探索.
- 由真菌衍生的奇托为生物材料开发提供了替代来源.
- 调查新的来源,如Hericium erinaceus和Pleurotus ostreatus的.研究新的来源,如Hericium erinaceus和Pleurotus ostreatus的.
研究的目的:
- 描述和评估从体外真菌培养物 (Hericium erinaceus,Pleurotus ostreatus) 中提取的奇托作为抗菌基质.
- 为了评估真菌奇托桑的物理化学特性和抗菌疗效.
- 探索银纳米粒子修饰对增强抗菌活性的潜力.
主要方法:
- 从体外真菌培养物中提取基托桑.
- 使用BET (Brunauer-Emmett-Teller),SEM (扫描电子显微镜) 和FTIR-ATR (福里埃变换红外光谱学减弱的总反射率) 的物理化学表征.
- 通过抑制区直径对细菌菌株 (例如,大肠杆菌) 的抗菌活性评估.
主要成果:
- 与Hericium erinaceus (0.39 m2/g) 和商用奇托桑 (1.16 m2/g) 相比,Pleurotus ostreatus奇托桑的特定表面积较高 (0.73 m2/g).
- P. ostreatus 奇托桑对格拉姆阴性和格拉姆阳性细菌表现出显著的抗菌活性.
- 银纳米粒子修饰P. ostreatus奇托桑增加了25% (18.2±0.5毫米抑制区) 的抗菌疗效对大肠杆菌.
结论:
- 由真菌衍生的奇托,特别是来自P. ostreatus,作为具有实质性抗菌性能的有前途的生物活性基质.
- 银的修饰增强了真菌奇托桑的稳定性和抗菌性能.
- 这些发现支持P. ostreatus在需要抗微生物活性的生物医学应用中潜在地使用奇多.
相关概念视频
01:24Microbial Corrosion
Microbiologically Influenced Corrosion (MIC) is a significant form of material degradation caused by the metabolic activities of microorganisms. This phenomenon poses substantial challenges across various industries, including oil and gas, maritime, and water treatment sectors.MIC occurs when microorganisms, such as bacteria, archaea, and fungi, colonize metal surfaces, forming biofilms that alter the local electrochemical environment. These biofilms can lead to the production of corrosive...
01:15Antifungal Agents
Amphotericin B is a broad-spectrum antifungal agent that exploits structural differences between fungal and mammalian cell membranes. Its amphipathic structure—featuring a hydrophobic polyene-lactone ring and a hydrophilic region containing mycosamine and carboxylic acid groups—enables selective binding to ergosterol, a sterol predominantly found in fungal plasma membranes. This selective interaction underlies the drug’s antifungal activity, although weak binding to cholesterol contributes to...