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基于以基体的体系统用于通过皮肤传递:生物活性剂在增强稳定性和有效性方面的作用
Jagoda Chudzińska-Skorupinska1, Agata Wawrzyńczak1, Agnieszka Feliczak-Guzik1
1Department of Applied Chemistry, Faculty of Chemistry, Adam Mickiewicz University in Poznań, Uniwersytetu Poznańskiego 8, 61-614 Poznań, Poland.
Materials (Basel, Switzerland)
|December 11, 2025
概括
优化以特定的酒精,糖醇和表面活性剂来优化以体的配方,可显著提高通过皮肤递送药物的稳定性和性能. 同质化进一步提高了囊泡大小的均性,并减少了聚合.
科学领域:
- 制药科学 制药科学
- 材料科学 材料科学 材料科学
- 生物技术是生物技术.
背景情况:
- 通过皮肤递送药物面临的挑战是由于角层的屏障特性.
- 乙体是先进的囊泡载体,旨在克服这些障碍并改善皮肤药物生物可用性.
- 优化以索姆配方对于提高其物理化学稳定性和治疗疗效至关重要.
研究的目的:
- 系统地优化ethosome组成和制备参数,以提高稳定性和透皮性能.
- 调查各种酒精,甘醇和表面活性剂对以体特征的影响.
- 评估脂度和同质化在以体配方中的作用.
主要方法:
- 对酒精 (例如,乙醇) 和糖醇 (例如,乙烯糖醇) 的系统选.
- 评估表面活性剂系统,包括Tween 80和生物表面活性剂,如Mirasoft® SL L60.
- 使用泽塔潜力 (ZP),多分散度指数 (PDI) 和水力动力直径 (Dh) 的物理化学稳定性评估.
- 扫描电子显微镜 (SEM) 用于囊泡形态分析.
- 优化脂度和同质化技术的优化.
主要成果:
- 通过使用30%的乙醇,2.5%的脂,10%的乙烯糖醇和1.25%的Tween 80. 80之间确定了最佳配方.
- 混合表面活性剂系统的稳定性可比,这表明对传统表面活性剂的依赖性减少.
- 同质化显著改善了体稳定性,将PDI从0.366降低到0.083,Dh从254nm降低到156nm.
- SEM证实了准备好的以索姆的球形形态.
结论:
- 乙体配方成分和加工条件是稳定性和透皮输送效率的关键决定因素.
- 经过优化后的以索姆体表现出增强的物理化学特性,包括更好的尺寸均性和减少聚合.
- 这些发现支持量身定制的以索姆的潜力,用于有效的通过皮肤递送药物的应用.
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