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血管内皮功能障碍的评估在使用臂膜流介导扩张的败血症患者:系统性审查和元分析

Lana Kattan¹, Sara Abulola¹, Mohamed H Elsayed¹

¹Department of Pharmaceutical Sciences, College of Pharmacy, QU Health, Qatar University, Doha P.O. Box 2713, Qatar.

Diagnostics (Basel, Switzerland)

|December 11, 2025

概括

流媒扩张 (FMD) 在败血症患者中较低,表明内皮功能障碍. 这种标志物在败血症未幸存者中显著减少,突出其预后潜力.

科学领域:

心血管生理学心血管生理学
临界护理医学临界护理医学
血管生物学血管生物学

背景情况:

败血症是全球死亡的主要原因,需要早期风险分层和预后.
内皮功能障碍是败血症的一个关键特征,可能是器官衰竭的前兆.
支臂流介导扩张 (FMD) 量化了内皮依赖的血管扩张,并反映了内皮功能.

研究的目的:

系统地审查和元分析有关口和口病在血症中评估血管内皮功能障碍的证据的有效性.
为了比较 FMD 败血症患者和非败血症对照.
为了比较 FMD 败血症幸存者和非幸存者之间.

主要方法:

在PubMed,Embase,Scopus和Web of Science的系统文献搜索到2024年11月.
包括临床研究测量 FMD 在败血症患者.
随机效应模型元分析和纽卡斯尔-太华尺度用于质量评估.

主要成果:

包括8项研究,其中7项正在进行定量合成 (385名败血症患者).
与非败血症对照组相比,败血症患者表现出明显较低的口病 (SMD = -2.1617,p=0.0113).
败血症的非幸存者比幸存者显示的口病明显低 (SMD = -0.7003,p=0.001).

结论:

败血症患者的下部口病表明,它有可能成为内皮功能障碍的替代标记物.
在非幸存者中减弱的口病表明其在败血症预后和风险评估中的有用性.
FMD 测量提供了一种非侵入性的方法来评估败血症中的血管健康.

关键词:

内皮质功能障碍在内皮质功能障碍通过流介导的扩张.这是一种血症.败血症的冲击是一个令人震惊的现象.

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