在糖尿病足中不利结果的预测因素
Renata Pauliukienė1, Kristina Šutienė2, Aistė Čemerkaitė3
1Department of Endocrinology, Faculty of Medicine, Medical Academy, Lithuanian University of Health Sciences, Eiveniu 2, LT-50161 Kaunas, Lithuania.
Diagnostics (Basel, Switzerland)
|December 11, 2025
概括
系统性因素,如炎症,功能障碍,脂质不良和先前截肢,显著预测糖尿病足的长期结果. 仅仅的特征对DFU预后具有有限的预测价值.
科学领域:
- 内分泌学和新陈代谢学
- 血管外科 血管外科
- 腎臟病學 (nephrology) 是一種醫學專業.
背景情况:
- 糖尿病足 (DFU) 是糖尿病的一个严重并发症.
- 识别预后因素对于管理DFU和预防不良结果至关重要.
研究的目的:
- 确定糖尿病足患者的长期结果的系统性,代谢性和宿主相关的预后因素.
- 分析各种临床,实验室和成像数据的预测重要性.
主要方法:
- 在426名患者中选择了100名患有DFU的患者队列.
- 随机森林和分类增强模型与SHAP值被用于预后因素分析.
- 结果被分为有利的 (愈合) 或不利的 (不愈合,再,截肢或死亡).
主要成果:
- 在平均2.1年的随访期间,53%的队列中出现了不良结果.
- 预后不佳的最强有力的预测因素包括先前截肢,炎症标志物升高,估计淋巴球过率 (eGFR) 降低和脂质失调.
- 甘油三醇显示出U形的关联;较低的BMI和较短的糖尿病持续时间矛盾地与较差的结果有关.
结论:
- 长期的DFU预后主要由系统性和宿主相关的因素决定,而不仅仅是的特征.
- 炎症,功能障碍,脂质失调 (尤其是甘油三) 和截肢史是不利的DFU结果的关键预测因素.
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