增加的担忧与自我报告,但不是告密者报告的主观认知衰退相关,预测事件痴呆症的风险增加
Katya T Numbers1, Ben C P Lam2, Suraj Samtani1
1Centre for Healthy Brain Ageing (CHeBA), Discipline of Psychiatry & Mental Health, School of Clinical Medicine, Faculty of Medicine & Health, University of New South Wales, Sydney 2052, Australia.
Diagnostics (Basel, Switzerland)
|December 11, 2025
概括
主观认知投诉 (SCC) 预测痴呆风险. 随着时间的推移,参与者越来越关注这一风险,这显着提高了这一风险,突出了对早期检测的纵向监测的重要性.
科学领域:
- 神经科学是一个神经科学.
- 老年学是指老年学的学科.
- 认知心理学 认知心理学
背景情况:
- 主观认知投诉 (SCC) 是未来痴呆症的关键预测因素.
- 该SCD-plus框架突出了认知关注和告知者的证实.
- 有限的研究已经探索了SCC关注的纵向变化.
研究的目的:
- 评估基线SCC关注及其纵向轨迹是否预测10年内发生的痴呆症.
- 为了区分参与者与 SCC 关注的告密者报告的预测值.
- 调查不断演变的主观认知经验的预后意义.
主要方法:
- 潜增长曲线建模分析了873名老年人 (平均年龄为78.65) 的SCC关注.
- 考克斯的比例危险模型在10年内检查了痴呆症风险.
- 对人口统计和临床因素进行控制的分析.
主要成果:
- 基线参与者和告知者SCC关注独立预测的痴呆症.
- 随着时间的推移,越来越多的参与者对SCC的担忧显著增加了痴呆症风险 (HR=10.23).
- 报告人关注度的变化并没有显著改变痴呆症风险预测.
结论:
- 参与者和 SCC 关注的告知者提供了对痴呆风险的独特预后信息.
- 监测参与者关注的纵向变化对于痴呆症风险评估至关重要.
- 演变的主观认知经验可能表明潜在的病理变化,支持临床实用性.
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