里图西马布诱导的间歇性肺病:一种可能被低估的并发症-系统性审查
Alexandra-Simona Zamfir1, Mihai-Vasile Marinca2,3, Carmen Lăcrămioara Zamfir4
1Department of Medical Sciences III, Pulmonology, Faculty of Medicine, "Grigore T. Popa" University of Medicine and Pharmacy, 700115 Iasi, Romania.
Cancers
|December 11, 2025
概括
里图西马布诱导的间歇性肺病 (R-ILD) 是一种罕见但严重的并发症. 早期诊断和多学科管理,通常是用皮质类固醇,对于患者的结果至关重要.
科学领域:
- 肺部病理学 肺部病理学
- 免疫学 免疫学 免疫学
- 药理学 药理学是指药理学的学科.
背景情况:
- 利图西马布是一种向CD20的单克隆抗体,它改变了B细胞疾病的治疗方法.
- 肺部不良事件,包括Rituximab诱导的间歇性肺病 (R-ILD),是显著的风险.
- 由于非特异性症状和成像,诊断R-ILD很困难.
研究的目的:
- 系统地审查有关R-ILD的现有证据.
- 分析R-ILD发生率,诊断,管理和结果.
- 为了综合R-ILD在接受Rituximab治疗的患者中的数据.
主要方法:
- 在2025年8月之前对PubMed/MEDLINE文献进行系统审查.
- 搜索术语:"rituximab诱导的间歇性肺部疾病".
- 分析了40项研究,包括案例报告,系列和队列研究.
主要成果:
- R-ILD发生在恶性和自身免疫性疾病中,通常与组合疗法一起发生.
- 放射学发现是多样化的,地面玻璃的不透明度是常见的.
- 大多数病例是可逆的,但进展和致命的结果是可能的;预防性trimethoprim-sulfamethoxazole可以预防肺炎.
结论:
- R-ILD是一种罕见但显著的rituximab并发症.
- 早期识别和多学科护理至关重要.
- 皮质类固醇是有效的,但严重的病例可能导致呼吸衰竭或死亡.
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