通过肠道微生物组调节前列腺癌治疗:综合性审查
Mohammed A Magashi Ali1, Sarki A Abdulkadir2,3
1Institute of Internal Medicine, Faculty of Medicine, University of Debrecen, 4032 Debrecen, Hungary.
Cancers
|December 11, 2025
概括
肠道微生物组显著影响前列腺癌治疗的有效性和副作用. 了解这种联系可能会导致新的疗法,改善患者的治疗结果并减少毒性.
科学领域:
- 在瘤学瘤学.
- 微生物学 微生物学
- 免疫学 免疫学 免疫学
背景情况:
- 对肠道微生物组在癌症中的作用越来越感兴趣.
- 专注于其对前列腺癌治疗结果和治疗诱导的微生物变化的影响.
研究的目的:
- 审查肠道微生物群如何调节前列腺癌治疗结果.
- 检查前列腺癌疗法如何影响肠道微生物组成.
主要方法:
- 半系统的PubMed搜索 (2010-2025) 的英语文章.
- 包含原始研究和评论,并进行引用跟踪.
- 关键词:前列腺癌治疗,肠道微生物组.
主要成果:
- 肠道微生物组与前列腺癌疗法之间的双向关系.
- 微生物通过免疫调节,新陈代谢和生物活性化合物 (例如SCFA,托衍生物) 来调节治疗疗效/毒性.
- 前列腺癌治疗改变了微生物组合,减少了多样性,增加了透性,可能会影响结果. 特定的种类如Akkermansia muciniphila,Faecalibacterium和Bacteroides都涉及到这一问题.
结论:
- 互惠的肠道微生物-前列腺癌治疗影响提供了治疗创新潜力.
- 在前列腺特异性研究中存在重大证据缺口;目前的数据主要来自临床前/跨癌症研究.
- 需要进行翻译性研究,以通过利用微生物组调制来个性化前列腺癌治疗,以提高疗效和降低毒性.
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