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生殖尿道微生物组和挥发性细胞组:一项针对前列腺腺癌患者进行激进前列腺切除术的试点研究

Layla Musleh^1,2, Sara Passerini¹, Francesca Brunetti¹

¹Department of Public Health and Infectious Diseases, Microbiology Section "Sapienza" University of Rome, P. le Aldo Moro 5, 00185 Rome, Italy.

|December 11, 2025

概括

尿路微生物组和代谢组的差异区分前列腺癌 (PC) 和良性前列腺增生 (BPH). 这些发现表明PC中潜在的微生物群-代谢物相互作用,需要在更大的研究中进一步调查.

科学领域:

泌尿器科泌尿器科泌尿器科泌尿器科
微生物学微生物学
代谢学代谢学代谢学
在瘤学瘤学.

背景情况:

生殖尿路微生物组和代谢组在前列腺癌 (PC) 中的作用尚未得到充分探索.
在PC与良性前列腺增生 (BPH) 中,尿道和组织微生物和代谢资料的证据有限.

研究的目的:

在患有PC的男性中描述尿路微生物群和挥发性细胞.
为了研究前列腺组织中的微生物和病毒DNA.
为了比较PC和BPH患者之间的这些个人资料.

主要方法:

预计将招募21名PC患者和17名BPH对照患者.
对尿液和前列腺组织进行病毒DNA (多种病毒),细菌16SrRNA基因测序和尿液挥发性有机代谢物 (VOM) 的分析.
在PC和BPH组之间比较微生物和代谢资料.

主要成果:

在PC患者的尿液和组织中检测到JCPyV和BKPyV;在组织中很少发现MCPyV.
PC患者表现出更高的尿路微生物多样性和独特的代谢途径.
在PC和BPH之间观察到36种尿液VOM中的14种存在显著差异,PC相关的细菌和代谢物之间存在相关性.

结论:

尿道,而不是组织,微生物和挥发体的签名显示PC和BPH之间的区别更清楚.
结果表明PC中可能存在微生物群-代谢物相互作用.
需要在更大的队列中进一步验证.

关键词:

在HPyVs中生殖尿道微生物组前列腺癌是前列腺癌.性传播病原体的性传播病原体.挥发性代谢物的挥发性代谢物.

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