没有的劳动马的MCP/MTP关节的退行性变化:整合基于CT的评估和交尾液体生物标志物
Lazar Marković1, Ivan Vićić2, Mirjana Lazarević Macanović3
1Department of Equine, Small Animal, Poultry and Wild Animal Diseases, Faculty of Veterinary Medicine, University of Belgrade, Bulevar oslobođenja 18, 11000 Belgrade, Serbia.
Animals : an open access journal from MDPI
|December 11, 2025
概括
临床上健全的工作马经常在下腿关节中表现出早期关节退化. 这些变化与细胞数量增加和氧化应激有关,而不是矩阵金属蛋白酶活性.
科学领域:
- 兽医医学 兽医医学 兽医医学
- 马类骨科 马类骨科 马类骨科
- 生物化学 生物化学
背景情况:
- 工作马容易发生关节退化,但研究是有限的.
- 了解马关节 (MCP) 和马关节 (MTP) 关节的早期变化对于马的福利至关重要.
研究的目的:
- 描述塞尔维亚山马MCP/MTP关节的退行性变化.
- 调查关节变化和突液 (SF) 生物标志物之间的关联.
主要方法:
- 从8匹临床健康的马身上对32个MCP/MTP关节进行横截面研究.
- 计算机断层扫描 (CT) 用于关节成像.
- 对粘度,蛋白质,核细胞总数 (TNCC),氧化应激标志物和矩阵金属蛋白酶 (MMP) 活性进行SF分析.
主要成果:
- 亚冠状硬化症是普遍的,在年轻的马 (<9岁) 中更常见.
- 骨质植物症发生在三分之二的关节中,与体重相关,并与TNCC升高,总氧化剂状态和氧化应激指数相关.
- 低β-基酸盐水平是这两种变化的关键相互作用因素;MMP活性没有显示任何关联.
结论:
- 临床上健全的工作马通常表现出早期退行性关节变化.
- 这些变化与TNCC和氧化应激生物标志物的轻微增加有关.
- 进一步研究像β-基酸盐这样的代谢因素的作用是有必要的.
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