芬瑞诺在脏移植患者中的有效性和安全性
Serdar Kahvecioglu1, Huseyin Celik2, Asena Serap Yalcinkaya1
1Nephrology Department, Bursa Yüksek İhtisas Trainig and Research Hospital, Bursa 16310, Turkey.
Journal of clinical medicine
|December 11, 2025
概括
芬瑞诺在移植患者减少蛋白尿症方面表现有前途. 建议在初始治疗期间密切监测诸如高卡利米亚等副作用.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 药理学 药理学是指药理学的学科.
- 移植 移植 移植 移植
背景情况:
- 费内伦是一种非类固醇矿物质皮质类受体对抗剂,已被认可用于治疗慢性病 (CKD).
- 它在移植接受者 (KTRs) 中的安全性和有效性以前没有被研究过.
- 这项研究解决了关于KTRs中finerenone使用的知识差距.
研究的目的:
- 为了评估费内伦在脏移植接受者的安全性和有效性.
- 评估菲内伦对KTRs蛋白尿和功能的影响.
- 为了在这个人群中识别与菲内伦治疗相关的潜在不良影响.
主要方法:
- 一项比较性研究涉及15名接受过脏移植的接受者,接受过费内伦治疗和15名匹配的对照.
- 患者同时接受芬龙和ACE抑制剂或ARBs.
- 关键参数包括蛋白尿,功能和血清的监测持续了六个月.
主要成果:
- 在6个月后,费内伦显著减少了蛋白尿症的40% (p < 0.05).
- 没有观察到估计的淋巴细胞过率 (eGFR) 或血清肌素的显著变化.
- 不良事件包括在5.1%的患者中断治疗,在10.2%的患者中出现严重的高血症.
结论:
- 菲内伦是一种潜在的辅助疗法,用于减少移植患者的蛋白尿症.
- 当患者耐受时,它似乎可以保持功能.
- 密切监测不良影响,特别是高胆血症,在finerenone启动期间至关重要.
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