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Preoperative ManagementThe primary goals of preoperative management in kidney transplantation are to optimize the patient’s metabolic state and prepare them for surgery through diet adjustments, necessary dialysis, and tailored medical treatment. This phase also involves comprehensive infection screening and patient education about the surgical procedure and postoperative care to improve outcomes and adherence.Medical ManagementA comprehensive evaluation is required for both the living...
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在双边顺序肺移植的手术内外体外生命支持.

Tomislav Kopjar1,2, Feda Dzubur2,3, Dorian Hirsl4

  • 1Department of Cardiac Surgery, University Hospital Center Zagreb, 10000 Zagreb, Croatia.

Journal of clinical medicine
|December 11, 2025
PubMed
概括

在肺移植中常规使用中央静脉外体生命支持 (VA ECLS) 是安全的和可行的. 这种方法表明,初级移植功能障碍很低,肺移植受体的长期生存率很有希望.

关键词:
身体外生命支持身体外膜氧化氧化肺部移植 肺部移植主要的移植功能障碍.幸存率 幸存率 生存率

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科学领域:

  • 心血管外科心血管外科
  • 肺部医学 肺部医学
  • 移植手术 移植手术

背景情况:

  • 术内静脉外体生命支持 (VA ECLS) 传统上支持不稳定的肺移植患者.
  • 新出现的证据表明,对于所有肺移植接受者来说,常规的手术内VA ECLS具有潜在的益处.

研究的目的:

  • 评估肺移植期间常规中央VA ECLS的安全性和可行性.

主要方法:

  • 单中心回顾性观察研究 (2021年4月至2025年9月).
  • 包括连续的肺移植患者使用中央VA ECLS.
  • 在72小时使用ISHLT标准评估早期结果和初级移植功能障碍 (PGD).
  • 通过Kaplan-Meier估计报告的生存率和慢性肺异位移植功能障碍 (CLAD) 无生存率.

主要成果:

  • 35名患者成功移植中央VA ECLS;没有ECLS相关的并发症.
  • 在72小时内,严重的PGD发病率低 (11.4%).
  • 一年,三年和五年生存率:85%,74%,67%.
  • 一年,三年和五年没有CLAD的生存率:82%,52%,36%.

结论:

  • 常规中央VA ECLS的肺移植是安全的,PGD率较低.
  • 观察到有利的早期和中期结果.
  • 长期推断需要进一步的研究;技术正在发展.