糖尿病和慢性病:未来正在被超越
Alberto Martínez-Castelao1,2,3, José Luis Górriz4,5,6, Beatriz Fernández-Fernández2,7,8
1Nephrology Department, Bellvitge University Hospital, Hospitalet, 08907 Barcelona, Spain.
Journal of clinical medicine
|December 11, 2025
概括
糖尿病和慢性病是全球性的健康问题. 新的药物类别正在出现,以减缓进展和降低心血管风险,为患者提供新的希望.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學.
- 内分泌学 在内分泌学.
- 心脏病学 心脏病学
背景情况:
- 糖尿病 (DM) 和慢性病 (CKD) 是全球重要的健康挑战.
- 对于预防DM和CKD患者末期功能衰竭的治疗选择有限.
研究的目的:
- 对DM和CKD的脏保护剂进行主要临床试验进行审查.
- 为了总结DM,肥胖和心力衰竭的新兴新型药物与脏益处.
主要方法:
- 审查主要的临床试验和新兴药物开发在DM和CKD.
- 对当前和新型治疗类别的分析,包括ACEI/ARB,SGLT2抑制剂,GLP-1 RA,ET1R抗剂和MRA.
主要成果:
- 已建立的疗法 (ACEI/ARB,SGLT2抑制剂,GLP-1 RA,ET1R抗剂,芬瑞) 在减少白蛋白尿和蛋白尿方面表现出有效性.
- 新型药物如非类固醇MRA,阿尔多氨酸合成酶抑制剂,其他GLP-1RA,ET1R抗体和可溶性酸环酶激活剂正在开发中.
结论:
- 新兴疗法旨在进一步减缓疾病的进展,并降低DM和CKD患者的心血管风险.
- 未来的战略强调综合,以患者为中心,个性化的方法来管理病和并发症.
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