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不同灌剂在关节缩中的临床有效性:系统性审查和元分析
Miglė Miškinytė1, Inesa Stonkutė1, Vėjūnė Rupeikaitė1
1Faculty of Odontology, Medical Academy, Lithuanian University of Health Sciences, J. Lukšos-Daumanto 2, LT-50106 Kaunas, Lithuania.
Journal of clinical medicine
|December 11, 2025
概括
关节 (TMJ) 关节切除术有效治疗疼痛并改善功能. 臭氧化水提供了最强的长期缓解疼痛的方法,尽管所有灌剂的最大口腔开口改善并不显著.
科学领域:
- 口腔和牙面部外科手术
- 疼痛管理 疼痛管理
- 再生医学是一种再生医学.
背景情况:
- 关节 (TMJ) 疾病导致广泛的面部疼痛和功能障碍.
- 关节切除术是当保守治疗失败时,对于关节疾病的最小侵入性手术选择.
- 不同的灌剂,包括普通盐水,林格的乳酸盐和臭氧化水,都用于关节切开,每个都有潜在的益处.
研究的目的:
- 系统地评估和比较用于关节关节障碍的关节切开术的不同灌剂的有效性.
- 评估普通盐水,林格的乳酸盐和臭氧化水对减轻疼痛和功能恢复的影响.
主要方法:
- 在PubMed和ScienceDirect进行了遵循PRISMA指南的系统文献搜索.
- 在过去十年内以英语出版的研究包括在内,重点是使用指定的灌剂治疗关节关节障碍的关节缩.
- 分析了7项涉及220名患者的临床试验,其中3项试验提供了用于元分析的数据.
主要成果:
- 所有评估的灌剂都显示出疼痛 (VAS) 和最大口腔开口 (MMO) 的改善.
- 臭氧化水在减轻疼痛 (6.2分) 和MMO增益 (12.9毫米) 方面显示出最强的平均改善.
- 定量分析表明,臭氧化水提供了统计学上显著的长期减轻疼痛 (3-6个月),但MMO改善并不显著.
结论:
- 关节切开术,无论使用哪种灌剂,都能为关节疾病提供症状缓解.
- 臭氧化水似乎是最有效的灌剂,用于治疗关节关节炎的长期疼痛.
- 进一步的大规模,标准化的随机对照试验是必要的,以确认这些发现和优化治疗方案.
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