在接受Allo-HSCT的患者中,明显的肠主导指纹:临床结果的动态,预测因素和影响
Alexandre Soares Ferreira Junior1, Danielle Amanda Niz Alvarez1, Larissa da Silva Souza1
1Laboratory of Immunomodulation and Microbiota, Department of Genetics, Microbiology and Immunology, Institute of Biosciences, Sao Paulo State University, Botucatu 18618-970, SP, Brazil.
Journal of clinical medicine
|December 11, 2025
概括
像Bacteroides这样的属在肠道中占主导地位,在巴西患者中很常见,这些患者接受了全源造血干细胞移植 (allo-HSCT). 这种主导地位没有影响生存率或移植与宿主疾病,这表明该群体中存在独特的微生物群模式.
科学领域:
- 微生物组研究的研究.
- 造血干细胞移植 造血干细胞移植
- 胃肠道的健康状况
背景情况:
- 菌的统治在异性造血干细胞移植 (allo-HSCT) 中得到了充分研究.
- 在all-HSCT患者中,其他主要肠道属的患病率和临床意义不太清楚.
- 微生物群组成的地理差异可能会影响结果.
研究的目的:
- 为了研究肠道主导的动态,预测因素和临床影响,在巴西患者接受allo-HSCT.
- 在这个患者队列中识别超出Enterococcus的主导细菌属.
- 评估肠道主导和整体存活率或急性移植对宿主疾病 (aGvHD) 之间的关联.
主要方法:
- 在巴西四个中心进行前性研究.
- 从合金前HSCT到移植后六个月的便样本的纵向采集.
- 16S rRNA基因测序用于肠道支配性识别;用于预测分析的逻辑回归.
主要成果:
- 在192个便标本中,68%显示肠道主导.
- 占主导地位的属包括Bacteroides,Akkermansia,Phascolarctobacterium和Escherichia-Shigella. 这三种类型的细菌有着很大的影响力.
- 没有发现这些属的统治与整体存活率或aGvHD发病率之间的显著关联.
结论:
- 巴西的allo-HSCT患者表现出明显的肠道主导特征.
- 没有患者特征可靠地预测肠道主导.
- 地理背景对于解释all-HSCT中的微生物群结果关联至关重要.
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