在COVID-19患者中,TSH水平与炎症标志物的相关性:一项回顾性研究
Bartosz Krajewski1, Martyna Kamińska1, Jakub Ligęzka1
1Student Scientific Society at the Department of Internal Medicine, Autoimmunological Diseases and Diabetology, Medical University of Silesia, 40-752 Katowice, Poland.
Journal of clinical medicine
|December 11, 2025
概括
甲状腺刺激激素 (TSH) 水平可能表明COVID-19的严重程度,与淋巴细胞计数和中性粒细胞与淋巴细胞比率 (NLR) 相相关. 血小板 (PLT) 水平在女性患者中也显示出相关性.
科学领域:
- 内分泌学 在内分泌学.
- 传染性疾病 传染性疾病
- 血液学 血液学 血液学
背景情况:
- 由SARS-CoV-2引起的COVID-19可以引发严重的全身炎症和多器官功能障碍.
- 以前的研究表明,较低的甲状腺刺激激素 (TSH) 水平与COVID-19严重程度的增加之间存在联系.
研究的目的:
- 研究甲状腺刺激激素 (TSH) 水平与COVID-19患者各种炎症标志物之间的关联.
- 探索TSH作为COVID-19疾病严重程度的潜在生物标志物.
主要方法:
- 在2020年至2023年期间入院的105名COVID-19患者的回顾性研究.
- 评估TSH水平与白细胞计数 (WBC),血小板计数 (PLT),C反应蛋白 (CRP),D-二次体,公素,淋巴细胞计数/百分比和中性粒细胞与淋巴细胞比率 (NLR) 一起进行.
主要成果:
- 淋巴细胞计数与TSH正相关 (p=0.0038),而NLR与COVID-19患者负相关 (p=0.04682).
- 血小板 (PLT) 计数在女性亚组中与TSH呈正相关性 (p=0.0384).
- CRP,D-二次体,WBC,淋巴细胞百分比和前素与TSH水平没有统计学上显著的相关性.
结论:
- 在SARS-CoV-2感染个体中,TSH水平可能与淋巴细胞计数和NLR有关.
- TSH也可能与血小板计数相关,特别是在女性COVID-19患者中.
- 虽然TSH显示出作为严重性生物标志物的潜力,但需要进一步的研究,考虑到其他炎症指标.
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