从1990年到2021年,东亚的血液恶性瘤负担
James Fan Wu1, Frances Dominique V Ho2,3, Rod Carlo Columbres4,5
1Division of Hematology and Oncology, Department of Medicine, Medical College of Wisconsin, 8701 Watertown Plank Rd, Milwaukee, WI 53226, USA.
Journal of clinical medicine
|December 11, 2025
概括
东亚的血液性恶性瘤 (HMs) 主要来自中国和日本. 虽然整体死亡率下降,但多发性骨髓瘤的发病率和死亡率在中国和其他东亚国家显著增加.
科学领域:
- 血液学 血液学 血液学
- 流行病学 流行病学
- 公共卫生 公共卫生
背景情况:
- 血液性恶性瘤 (HM) 包括各种血液,骨髓和淋巴细胞瘤.
- 了解东亚的HM负担对于有针对性的公共卫生干预至关重要.
研究的目的:
- 从1990年到2021年,分析东亚HM的发病率,死亡率和残疾调整寿命年 (DALYs).
- 确定东亚国家在人力资源负担方面的趋势和差异.
主要方法:
- 利用的疾病,伤害和风险因素的全球负担研究2021年数据.
- 提取了2021年和1990-2021年HM的趋势估计 (白血病,多发性髓瘤,非霍奇金淋巴瘤,霍奇金淋巴瘤).
- 分析了东亚发生率,死亡率和DALYs的总计数和年龄标准化率.
主要成果:
- 中国和日本对全球HM负担做出了重大贡献.
- 非霍奇金淋巴瘤和白血病占HM病例,死亡和DALYs的大多数.
- 年龄标准化发病率 (ASIR) 一般上升,而死亡率 (ASMR) 和DALY率 (ASDALYR) 降低,除了多发性骨髓瘤 (MM).
- 蒙古,台湾和中国的MMASIR,ASMR和ASDALYR显著增加 (中国增加了200-300%).
结论:
- 在中国和日本诊断和治疗HMs需要全球卫生重点,因为他们的实质性负担.
- 东亚多发性骨髓瘤的负担日益增加,需要有针对性的公共卫生战略.
- 由于东亚国家之间观察到的差异,国家和疾病特定的调查是有必要的.
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