综合体质指数组对败血症结果的比较分析:一项回顾性队列研究
Abdulmajeed M Alshehri1,2,3, Lama Alfehaid1,2,3, Saad Alhamdan1
1Department of Pharmacy Practice, College of Pharmacy, King Saud bin Abdulaziz University for Health Sciences, Riyadh 11481, Saudi Arabia.
Journal of clinical medicine
|December 11, 2025
概括
败血症患者的体重指数 (BMI) 并没有显著影响重症监护室 (ICU) 死亡率或其他临床结果. 这项研究没有发现任何证据表明毒症患者的不同BMI类别的风险增加.
科学领域:
- 关键护理医学 关键护理医学
- 临床营养学 临床营养学
- 流行病学 流行病学
背景情况:
- 身体质量指数 (BMI) 和败血症结局之间的关联是有争议的,关于肥胖悖论和体重不足个体的风险有相互矛盾的报道.
- 现有的文献提出了一个有争议的观点,即BMI如何影响败血症患者的预后.
研究的目的:
- 研究身体质量指数 (BMI) 对重症监护室 (ICU) 败血症患者死亡率和其他临床结果的影响.
- 澄清BMI类别与败血症严重程度之间的关系,包括败血症休克和急性呼吸困扰综合征.
主要方法:
- 在2021年1月至2023年12月期间入住ICU的559名成人败血症患者的回顾性队列研究.
- 根据BMI,患者被分为体重不足,体重正常,超重和肥胖的组.
- 主要结局:ICU死亡率. 二次结局:败血性休克,ARDS,30/90天死亡率,ICU/住院时间长度,血管压缩器/无通风日.
主要成果:
- 在四个BMI组 (p > 0.05) 中,ICU死亡率没有显著差异.
- 二次结局,包括败血性休克,ARDS,死亡率和逗留时间,也没有显示出BMI类别之间的显著差异.
- 分析包括51名体重不足,206名体重正常,158名超重和184名肥胖患者.
结论:
- 体重指数 (BMI) 与败血症患者的不良临床结果无关.
- 建议进行进一步的大规模前性研究,以验证这些发现,并确认BMI与败血症预后缺乏关联.
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