在长期COVID中评估骨矿物质密度,总体组成和关节完整性:为期12个月的纵向可行性研究
Fahad Alghamdi1,2, Abasiama Dick Obotiba2, Robert Meertens2
1Department of Radiologic Technology, College of Applied Medical Sciences, Qassim University, Buraydah 52571, Saudi Arabia.
Journal of clinical medicine
|December 11, 2025
概括
长期COVID (LC) 患者的脂肪增加,但在12个月内没有显著的骨损失. 关节症状,如膝关节节膜缩,需要持续监测持续的肌肉骨健康问题.
科学领域:
- 肌肉骨健康 肌肉骨健康
- 传染病并发症 传染病并发症
- 代谢健康 代谢健康
背景情况:
- 在SARS-CoV-2感染后的持续症状,称为长期COVID (LC),可能包括肌肉骨 (MSK) 问题.
- 慢性炎症可能会影响骨代谢和关节健康,但经验证据有限.
- 液结合对肌肉的健康,骨和关节完整性的具体影响仍然不太清楚.
研究的目的:
- 为了研究长期COVID对肌肉骨功能的影响.
- 与恢复的对照人群相比,评估LC患者的骨健康,身体组成和关节完整性.
主要方法:
- 一个长达12个月的纵向前性队列可行性研究.
- 涉及45名患有LC的成年人和40名康复良好 (WR) 的COVID-19后对照.
- 使用双能X射线吸收计 (DXA) 检测骨矿物质密度 (BMD) 和总体构成 (TBC),并使用MSK超声波进行联合评估.
主要成果:
- 与对照组相比,LC组在骨头,手足和腿部区域中显示出更大的脂肪积累 (p < 0.01).
- 在LC患者中,基线下显著较低的膝关节突增大 (13.3%对比45%在WR中,p = 0.001).
- 在12个月的LC组中观察到手部突增大症的边际改善 (p = 0.012);在组之间或随时间的推移中,没有发现骨质量的显著差异.
结论:
- 长期的COVID似乎不会导致快速的骨质损失.
- 在LC中增加脂肪和关节症状需要持续监测.
- 未来的研究应该探索MSK标记物,肌肉功能,先进的成像和干预措施,以改善LC中的MSK健康.
更多相关视频
07:56Scanning Skeletal Remains for Bone Mineral Density in Forensic Contexts
Published on: January 29, 2018
18.1K
07:12Semiautomated Longitudinal Microcomputed Tomography-based Quantitative Structural Analysis of a Nude Rat Osteoporosis-related Vertebral Fracture Model
Published on: September 28, 2017
8.5K
相关概念视频
01:29Bone Disorders
5.0K
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
5.0K
01:31Essential Minerals for Bone Health
5.9K
The minerals contained in all of the food we consume are essential for our organ systems. However, certain essential minerals, such as calcium, phosphorus, magnesium, manganese, and fluoride, largely affect bone health.
Calcium and Phosphorus
Calcium is a critical component of bones, especially in the form of calcium phosphate and calcium carbonate. Since the body cannot make calcium, it must be obtained from the diet. However, calcium cannot be absorbed from the small intestine without...
Calcium and Phosphorus
Calcium is a critical component of bones, especially in the form of calcium phosphate and calcium carbonate. Since the body cannot make calcium, it must be obtained from the diet. However, calcium cannot be absorbed from the small intestine without...
5.9K
01:27Chronic Obstructive Pulmonary Disease-IV: Assessement and Diagnostic Studies
3.1K
Assessing and diagnosing Chronic Obstructive Pulmonary Disease (COPD) involves a detailed approach that includes a comprehensive review of medical history, physical examination, and a variety of diagnostic tests. This thorough evaluation is essential to ensure an accurate diagnosis and guide effective management strategies.
Medical History
Medical History
3.1K
02:20Longitudinal Research
13.0K
Sometimes we want to see how people change over time, as in studies of human development and lifespan. When we test the same group of individuals repeatedly over an extended period of time, we are conducting longitudinal research. Longitudinal research is a research design in which data-gathering is administered repeatedly over an extended period of time. For example, we may survey a group of individuals about their dietary habits at age 20, retest them a decade later at age 30, and then again...
13.0K