艾滋病毒感染患者的真菌感染-它仍然是一个挑战吗?
Martyna Biała1, Natalia Słabisz2,3, Brygida Knysz1
1Department of Infectious Diseases, Liver Diseases and Acquired Immune Deficiences, Faculty of Medicine, Wroclaw Medical University, 51-149 Wroclaw, Poland.
Journal of clinical medicine
|December 11, 2025
概括
真菌感染仍然是艾滋病毒/艾滋病患者的重大威胁,特别是那些未经治疗或管理不善的疾病患者. 全球抗真菌耐药性增加和免疫功能低下患者的增加加剧了这些挑战.
科学领域:
- 医学真菌学 医学真菌学
- 传染性疾病 传染性疾病
- 免疫功能受损的宿主感染
背景情况:
- 真菌感染是人类免疫缺陷病毒/获得免疫缺陷综合征 (HIV/AIDS) 患者常见的机会性感染.
- 某些特定的真菌,如肺囊菌 jirovecii,新型菌,囊囊菌,以及Candida spp. 不成比例地影响艾滋病毒感染个体.
- 虽然抗逆转录病毒治疗已经减少了侵入性真菌感染,但未接受治疗或不坚持治疗的患者仍然面临高风险.
研究的目的:
- 提供艾滋病毒阳性患者普遍存在的真菌感染的概述.
- 讨论这些感染的不断变化的流行病学和病因学.
- 突出当前的治疗挑战,包括不断增加的抗真菌耐药性.
主要方法:
- 关于艾滋病毒/艾滋病患者常见真菌感染的文献综述.
- 对流行病学趋势和病因学转变的分析.
- 讨论当前的治疗策略和挑战.
主要成果:
- 抗逆转录病毒疗法降低了艾滋病毒患者的侵入性真菌感染.
- 未经治疗或不良的艾滋病患者面临严重的并发症和死因真菌感染的死亡率.
- 越来越多的免疫受损患者和不断增加的抗真菌耐药性带来了越来越多的公共卫生问题.
结论:
- 在艾滋病毒/艾滋病管理中,真菌感染仍然是一个关键问题.
- 由于治疗坚持和更广泛的免疫受损人群,艾滋病毒真菌感染的景观正在发生变化.
- 解决抗真菌耐药性和优化治疗策略对于改善患者治疗结果至关重要.
更多相关视频
相关概念视频
Sexually Transmitted Infections
858
Sexually transmitted infections (STIs) are diseases transmitted primarily through unsafe sexual interactions. Bacteria, viruses, or parasites cause them and can result in severe health complications if untreated.ChlamydiaThe bacterium Chlamydia trachomatis is responsible for the disease Chlamydia, the most common STI in the United States. This peculiar pathogen requires human cells to reproduce, residing intracellularly. The initial infection often goes unnoticed because it typically does not...
858
Fungal Phylum Microsporidia
382
Microsporidia are a group of obligate intracellular fungi that were initially classified as protists but were later reclassified based on phylogenetic, molecular, and structural evidence linking them to the Chytridiomycota. These unicellular, non-motile organisms are highly specialized parasites that infect a wide range of animal hosts, including humans. They have evolved extensive genomic and metabolic reductions, making them highly dependent on their hosts for survival.Morphology and Genomic...
382
Pulmonary Tuberculosis I
802
Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
802
Immunodeficiency Diseases
1.9K
Immunodeficiency disorders are conditions in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent. The immune system comprises a complex network of cells, tissues, and organs that work together to protect the body from potentially harmful invaders. When this system is deficient or not functioning properly, it leaves the body susceptible to infections, diseases, or other complications.
There are three main causes of immunodeficiency...
There are three main causes of immunodeficiency...
1.9K
Retrovirus Life Cycles
49.1K
Retroviruses have a single-stranded RNA genome that undergoes a special form of replication. Once the retrovirus has entered the host cell, an enzyme called reverse transcriptase synthesizes double-stranded DNA from the retroviral RNA genome. This DNA copy of the genome is then integrated into the host’s genome inside the nucleus via an enzyme called integrase. Consequently, the retroviral genome is transcribed into RNA whenever the host’s genome is transcribed, allowing the...
49.1K


