乳酸注入对新陈代谢,阿尔茨海默病生物标志物和认知的急性影响:LEAN研究
Riley E Kemna1,2,3, Paul J Kueck1,2, Anneka Blankenship1,2
1University of Kansas Alzheimer's Disease Research Center, Fairway, Kansas, USA.
Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 11, 2025
概括
阿尔茨海默病患者的乳酸代谢与健康个体相似. 乳酸注入改善了认知能力,并减少了阿尔茨海默氏症的关键生物标志物,这表明潜在的治疗益处.
科学领域:
- 神经科学是一个神经科学.
- 代谢研究的研究.
- 生物标志物的分析分析.
背景情况:
- 大脑葡萄糖代谢受损是阿尔茨海默病 (AD) 的特征.
- 乳酸作为一种替代的大脑燃料,但其在阿尔茨海默病中的全身新陈代谢研究不足.
- 研究乳酸代谢为了解AD病理生理学提供了一种新的方法.
研究的目的:
- 评估认知障碍或没有认知障碍的个体的全身乳酸代谢.
- 评估乳酸输注对认知功能和AD相关液体生物标志物的影响.
- 探索乳酸作为阿尔茨海默氏病的潜在治疗剂.
主要方法:
- 能量和神经认知乳酸试验 (NCT05207397) 涉及对认知健康 (CH) 和认知受损 (CI) 参与者的稳定同位素乳酸输液.
- 进行了脑脊液 (CSF) 和血生物标志物的认知测试和分析,包括pTau217,BD-tau,pTau181,GFAP,NFL,总tau和BDNF.
- 使用Simoa HD-X技术进行了精确的生物标志物量化.
主要成果:
- 乳酸代谢清除率在CH和CI组之间是可比的.
- 乳酸注入后,全球认知表现显著改善 (p < 0.001).
- 输液后,包括pTau217,BD-tau,pTau181,GFAP和NfL在内的关键AD生物标志物的血水平显著降低.
结论:
- 乳酸代谢在有或没有认知障碍的个体之间没有显著差异.
- 乳酸盐输注显示了提高全球认知和处理速度的潜力.
- 乳酸输液导致阿尔茨海默病的液体生物标志物显著减少.
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