传染病原体与随后的癌症风险之间的关联从英国生物库的纵向分析
Ting Ao1, Nan Wu2, Yingxiu Huang1
1Department of Infectious Diseases, Beijing Luhe Hospital, Capital Medical University, Beijing, China.
International journal of surgery (London, England)
|December 11, 2025
概括
传染病原体与癌症风险有复杂的联系,有些病原体增加了风险,有些病原体降低了风险,通常因性别而异. 了解这些病原体与癌症的关联是有针对性的查和未来研究的关键.
科学领域:
- 在瘤学瘤学.
- 传染性疾病 传染性疾病
- 流行病学 流行病学
背景情况:
- 越来越多的证据表明,传染病原体有助于癌症的发展.
- 然而,病原体暴露和癌症发病率之间的长期关系尚未完全理解.
研究的目的:
- 调查各种病原体暴露的血清学证据与患26种不同类型癌症的风险之间的纵向关联.
- 探索这些病原体与癌症关系中的潜在的性别特异性.
主要方法:
- 在9,427名英国生物库参与者中,对20种病原体的血清学概况进行前性分析.
- 考克斯比例危险模型用于评估癌症风险,平均随访时间为13.7年.
- 根据人口和生活方式因素进行调整,以性别分层分析和多重测试的本雅米尼-霍赫伯格校正.
主要成果:
- 确定了不同的病原体与癌症的关联,其中许多显示出性别特异的模式.
- 肝炎C病毒 (HCV) 与肝癌有关; 杆菌 (H. pylori) 与胃癌有关; 人类乳头瘤病毒与口腔/鼻癌有关.
- 在几个疹病毒,HPV,HIV-1,HTLV-1,H. pylori抗原和结肠直肠癌/恶性免疫扩散性疾病之间发现了不良关联,主要在男性中. 对HCV,B型肝炎病毒和Chlamydia trachomatis与膀,/尿道和小细胞肺癌的特定关联,分别有某些性别特异性趋势.
结论:
- 血清学数据揭示了多种病原体与癌症的关联,突出了瘤发生过程中的复杂相互作用.
- 研究结果强调,需要在高风险群体中进行病原体特异性查.
- 需要进一步的机制研究来阐明感染在癌症发展中的复杂作用.
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