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在接种疫苗的医学学生中分析乙型肝炎免疫力

Nicole Gentile¹, Chandni Aghera¹, Haylie Smith¹

¹Edward Via College of Osteopathic Medicine - Carolinas Campus, Spartanburg, SC, USA.

Journal of osteopathic medicine

|December 11, 2025

概括

随着时间的推移,B型肝炎疫苗免疫力会减弱,特别是那些在较年轻时接种疫苗的人. 医学学生可能需要补充注射和定期标位查,以保持对乙型肝炎病毒 (HBV) 的保护.

科学领域:

肝病学肝病学是一种肝病学.
免疫学免疫学免疫学
公共卫生公共卫生

背景情况:

乙型肝炎病毒 (HBV) 感染带来风险,包括肝衰竭,肝硬化和肝细胞癌 (HCC).
医疗保健工作者和医学学生的暴露风险较高,需要强大的免疫力.
以前的研究表明,这些人群的HBV免疫力下降.

研究的目的:

调查影响疫苗接种医学生HBV免疫力降低的因素.
评估疫苗接种时间和标位测量间隔对免疫状况的影响.

主要方法:

在VCOM-Carolinas对1878名医学学生 (2011-2023) 的回顾性队列研究.
对疫苗接种日期,标位结果和免疫状况的分析.
统计方法包括威尔科克森的等级和,皮尔森的千平方和后勤回归.

主要成果:

在2011年至2023年期间,HBV非免疫率显著增加,从16.0%增加到61.3%.
在5岁前接种疫苗与5岁后接种疫苗 (11.3%) 相比,与较高的非免疫率 (47.8%) 相关.
接种疫苗后每年,非免疫的几率增加1.11 (p<0.001).

结论:

在HBV免疫接种后的延长时间与免疫力下降相关.
风险较高的医学学生可能会从定期的HBV标位查和及时的复发疫苗接种中受益.

关键词:

乙型肝炎 B 型肝炎免疫力是一种免疫力.医学院的学生医学院的学生接种疫苗的反应反应.

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