免疫相关的RELT通过JAK/STAT信号通路激活驱动清细胞细胞癌的进展
Yini Wang1,2, Yingying Yang2, Tianqi Wang2
1Yantai Affiliated Hospital of Binzhou Medical University, Yantai, Shandong, China.
Frontiers in immunology
|December 11, 2025
概括
瘤坏死因子受体超级家族成员19L (RELT) 在清细胞细胞癌 (ccRCC) 中高度表达,促进其发展和不良预后. RELT影响瘤免疫微环境,并可能作为ccRCC的新生物标志物.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 分子生物学分子生物学
背景情况:
- 清细胞细胞癌 (ccRCC) 是癌症相关死亡的一个重要原因.
- 瘤坏死因子受体超级家族成员19L (RELT) 在ccRCC病变中的作用及其对瘤免疫微环境的影响仍然不完全理解.
研究的目的:
- 调查RELT在ccRCC中的功能性作用.
- 探索ccRCC患者的RELT表达和临床预后之间的关联.
- 阐明RELT功能背后的机制及其对ccRCC瘤免疫微环境的影响.
主要方法:
- 利用基因表达总量 (GEO) 和癌症基因组图谱 (TCGA) 数据库进行差异表达分析.
- 进行了ex vivo和in vivo实验,以验证ccRCC中的RELT功能.
- 进行了途径分析 (GO,KEGG,GSEA) 和免疫透分析 (xCELL,EPIC,CIBERSORT,TIMER,TIDE).
主要成果:
- 在ccRCC组织中,RELT显著上调,与预后不佳相关.
- 功能性测试表明,RELT在ccRCC细胞中促进恶性生物行为.
- RELT影响幽默免疫,细胞化学反应,细胞因子调节,与B细胞,CD8+T细胞,CD4+T细胞和巨细胞等免疫细胞有关,影响瘤免疫微环境.
结论:
- RELT促进ccRCC的发展和进步.
- RELT在调节ccRCC瘤免疫微环境方面发挥着至关重要的作用,从而影响患者的预后.
- 在ccRCC中,RELT代表了一种潜在的新生物标志物,用于免疫透和预后.
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