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Updated: Jan 9, 2026

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由质介质细胞表达的IgA参与IgA脏病发病的发生

Haidong Zhang1, Zhenling Deng1, Yueming Gao1

  • 1Department of Nephrology, Peking University Third Hospital, Beijing, China.

Frontiers in immunology
|December 11, 2025
PubMed
概括

淋巴细胞介质细胞 (GMCs) 产生缺少银河糖的IgA1 (Gd-IgA1),通过TLR4通路促进IgA瘤病变 (IgAN) 的发生. 这挑战了多重命中假说,并提出了IgAN的新治疗点.

关键词:
在GMC有条件的IGHA淘汰赛小鼠中.在IgA脏病发作中,IgA脏病发作缺乏银河糖的IgA1其他非B型免疫球蛋白.在μMT小鼠中.

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