在社区获得的肺炎中肠道微生物群的改变和系统性炎症:一个前性肠肺轴研究
Xue-Qin Yang1, Qian Tang1, Yuan-Jun Xiong1
1Department of Pharmacy, Guangyuan Central Hospital, Affiliated Hospital of North Sichuan Medical College, Guangyuan, Sichuan, China.
Frontiers in immunology
|December 11, 2025
概括
社区获得性肺炎 (CAP) 与肠道微生物群的变化有关. 在CAP患者的肠道功能障碍与通过肠肺轴增加的LPS和全身炎症相关.
科学领域:
- 微生物学 微生物学
- 免疫学 免疫学 免疫学
- 肺部病理学 肺部病理学
背景情况:
- 关于肠道微生物群在社区获得性肺炎 (CAP) 中的作用的研究有限.
- 肠肺轴在CAP病原体中的机制需要进一步研究.
研究的目的:
- 为了研究肠道微生物群和CAP之间的关系.
- 探索肠肺轴在农业政策发展中的作用.
主要方法:
- 分析了来自CAP患者和健康对照者的便和血清样本.
- 使用了16S rRNA基因测序和酶相关免疫吸收试验 (ELISA).
主要成果:
- CAP患者表现出肠道微生物群α-多样性的减少和β-多样性的改变.
- 在CAP患者中观察到,短链脂肪酸产生细菌的丰度降低,脂多糖化物 (LPS),TNF-α和IL-6水平增加.
- 在CAP患者的肠道微生物群失调与增加的LPS转位和全身炎症有关.
结论:
- 肠道微生物群失调与CAP的病原性有关.
- 肠肺轴可能在CAP的发展中发挥重要作用.
- 准肠道微生物群可能是CAP的潜在治疗策略.
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