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工程纳米粒子调节细胞外矩阵和瘤微环境的免疫组件在癌症免疫治疗中

Bao-Toan Dang^1,2, Khang-Yen Pham³, Ai-Han Nguyen²

¹Department of Precision Medicine, School of Medicine, Sungkyunkwan University, Suwon 16419, Republic of Korea.

Biomaterials research

|December 11, 2025

概括

工程纳米粒子可以重新编程瘤微环境 (TME),以增强癌症免疫疗法. 这些纳米材料向免疫细胞和其他TME组件,克服治疗耐药性并改善治疗结果.

科学领域:

在瘤学瘤学.
免疫学免疫学免疫学
纳米技术纳米技术

背景情况:

癌症免疫疗法利用免疫系统,但由于免疫抑制性瘤微环境 (TME) 而面临限制.
TME含有多种细胞和非细胞成分,促进瘤生长和治疗耐药性.

研究的目的:

提供工程纳米粒子在调制TME用于增强癌症免疫疗法的全面概述.
突出纳米载体在向特定的TME组件和恢复抗瘤免疫力的潜力.

主要方法:

对TME调制纳米技术近期进展的回顾.
探索纳米粒子与细胞 (免疫细胞,纤维细胞) 和非细胞 (ECM,血管) TME组件的相互作用.

主要成果:

工程纳米粒子可以重新编程与瘤相关的免疫细胞 (T细胞,树突细胞,NK细胞,巨细胞).
纳米载体可以向与癌症相关的纤维细胞,重塑血管结构,降解细胞外基质,并中和免疫抑制媒介.
纳米材料通过重塑瘤景观,提供局部传递,降低毒性和提高治疗效率.

结论:

理性设计的纳米材料在癌症免疫疗法中克服TME介导的耐药性方面具有显著的前景.
针对挑战和安全考虑的进一步研究对于这些纳米技术的临床转化至关重要.

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