2型糖尿病患者的并发症发展轨迹:来自500万回顾性队列研究的证据
Haoqing Tang1,2, Mingyue Li1,2, Xiaokang Ji3
1Department of Health Policy and Management, School of Public Health, Peking University, Beijing, China.
Frontiers in health services
|December 11, 2025
概括
2型糖尿病 (T2DM) 的并发症在中国正在上升,大多数患者在十年内发展出多种问题. 定期检查和初级保健使用可以降低T2DM并发症风险.
科学领域:
- 公共卫生 公共卫生
- 流行病学 流行病学
- 慢性疾病管理 慢性疾病管理
背景情况:
- 2型糖尿病 (T2DM) 在中国是一个显著而不断升级的健康挑战.
- 高水平的T2DM并发症有助于增加发病率,死亡率和医疗保健成本.
- 有限的现实世界数据存在于T2DM并发症的发展和集群随着时间的推移.
研究的目的:
- 调查T2DM相关并发症的发展轨迹,发病时间和关键风险因素.
- 分析中国大量现实人口中的并发症模式.
- 确定影响T2DM并发症发展的因素.
主要方法:
- 使用来自Cheeloo Lifespan电子健康研究数据库的大数据的回顾性队列研究.
- 包括来自中国山东省的500多万个人.
- 对T2DM并发症轨迹,发病和风险因素的分析.
主要成果:
- T2DM并发症的发生率从30.4% (2013) 增加到53.1% (2023).
- 第一次并发症的中位时间为7.5年;大多数患者在第9年出现多次并发症.
- 眼科,神经和循环并发症是最常见的,并显示显著增加.
- 频繁的随访和初级卫生保健 (PHC) 使用是保护性的;未婚,超重/肥胖,酒精使用和不良药物坚持是危险因素.
结论:
- 中国的T2DM患者面临着大量且不断增长的并发症负担.
- 频繁的随访,PHC利用和药物坚持是潜在的保护因素.
- 综合,基于社区和个性化的管理策略对于改善T2DM结果至关重要.
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