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通过调节大鼠肠道微生物群,SCM-198可改善肺动脉高血压

Jianyu Xiong¹, Qinyang Ge¹, Bohan Fu¹

¹Laboratory of Drug Discovery from Natural Resources and Industrialization and Faculty of Chinese Medicine, Macau University of Science and Technology, Macau, China.

Journal of thoracic disease

|December 11, 2025

概括

SCM-198 (Leonurine) 通过改善肠道微生物群和调节血管通路,有效治疗肺动脉高血压 (PAH). 这项研究强调SCM-198作为一种潜在的PAH辅助疗法.

科学领域:

心血管研究研究心血管研究
微生物组研究微生物组研究
药理学药理学是指药理学的学科.

背景情况:

肺动脉高血压 (PAH) 是一种进展性疾病,导致肺血管重塑和炎症.
肠道微生物群的变化越来越多地被认为是PAH的病原体.
SCM-198 (尿素) 是一种潜在的治疗PAH的药物.

研究的目的:

为了研究SCM-198的治疗效果,在单克罗他林 (MCT) 诱导的PAH的老鼠模型上.
评估SCM-198对肠道微生物群组成的影响.
探索SCM-198在调节PAH中的血管信号通路中的作用.

主要方法:

建立了使用单克罗他林 (MCT) 的PAH大鼠模型.
用SCM-198 (50和100毫克/公斤) 进行3周的治疗.
通过16S rRNA测序评估了肺血管重塑,肠道微生物群,并使用网络药理学确定了目标/途径.

主要成果:

SCM-198显著降低了肺动脉壁厚度和血管重塑.
微生物群的多样性显示出恢复的趋势,特定细菌种群的丰度发生了变化.
网络药理学确定了关键目标 (例如,Akt1,Mmp9) 和途径 (例如,PI3K-Akt信号传递,炎症).

结论:

SCM-198通过调节肠道微生物群和血管信号来证明PAH的治疗潜力.
研究结果表明,SCM-198可以作为PAH的有前途的辅助疗法.
这项研究为SCM-198在PAH中有效性的机制提供了新的见解.

关键词:

肺动脉高血压 (PAH) 是一种肺动脉高血压.我们的肠道菌群是肠道菌群.莱昂林 (SCM-198) 是一种网络药理学网络药理学

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