血红蛋白与红细胞分布宽度比率与心脏手术后30天死亡率之间的关联
Xian-Dong Wang1, Xu Liu1, Xiong-Fei Xia1
1Faculty of Anesthesiology, Changhai Hospital, Naval Medical University, Shanghai, China.
Journal of thoracic disease
|December 11, 2025
概括
低血红蛋白与红细胞分布宽度比 (HRR) 独立预测心脏手术患者的30天死亡率. 这种新型生物标志物有助于风险分层,以改善临床决策.
科学领域:
- 心血管外科心血管外科
- 血液学 血液学 血液学
- 生物标志物 生物标志物
背景情况:
- 心脏手术后的术后死亡率是一个重大的临床挑战.
- 传统的风险评分往往缺乏足够的预测准确性来预测患者的结果.
- 血红蛋白与红细胞分布宽度比 (HRR) 是一种用于预后评估的新兴生物标志物.
研究的目的:
- 研究手术前血红蛋白与红细胞分布宽度比率 (HRR) 和红细胞分布宽度 (RDW) 与30天术后死亡率之间的关联.
- 确定HRR和RDW是否可以作为心脏手术患者死亡率的独立预测指标.
主要方法:
- 对926名接受心脏和大动脉手术的患者的回顾性分析.
- 从电子健康记录中提取人口统计,并发症和外科手术期间的数据.
- 应用多变量逻辑回归和卡普兰-梅尔生存分析来评估HRR-死亡率关系和30天生存率.
主要成果:
- 30天死亡率为4.2%. 这是4.2%.
- 术前HRR≤8.73独立地与30天死亡率增加有关 (OR,0.1;P=0.047).
- 较高的RDW (>14.8%) 也与较高的死亡风险相关,Kaplan-Meier分析显示,低HRR组的累积死亡率明显更高 (9.6%对2.9%;P=0.001).
结论:
- 手术前HRR是心脏手术中30天死亡率的重要独立预测因子.
- 低HRR (≤8.73) 可以用于增强风险分层和临床决策.
- 需要进一步的研究来验证这些发现,并阐明潜在的病理生理机制.
相关概念视频
Oxygen Transport in the Blood
5.8K
Hemoglobin (Hb) is a crucial molecule in the human body, consisting of four polypeptide chains, each bound to an iron-containing heme group. This unique structure enables hemoglobin to bind to oxygen, with each molecule capable of combining with four molecules of oxygen, leading to rapid and reversible oxygen loading. When fully loaded with oxygen, it is called oxyhemoglobin, while hemoglobin that has released oxygen is called reduced hemoglobin or deoxyhemoglobin. As hemoglobin binds oxygen,...
5.8K
Hemoglobin
7.3K
Hemoglobin is a globular protein made up of four subunits. Two of these subunits are alpha chains, and the other two are beta chains. Each subunit contains a molecule of heme, which has an iron atom and can bind to oxygen. When an oxygen molecule binds to one heme group, it changes the shape of hemoglobin, making it easier for the other heme groups to bind oxygen as well.
When all four heme groups are bound to oxygen, the resulting molecule is called oxyhemoglobin. As a result, arterial blood...
When all four heme groups are bound to oxygen, the resulting molecule is called oxyhemoglobin. As a result, arterial blood...
7.3K
Blood Studies for Cardiovascular System I: Cardiac Biomarkers
758
Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
758
Hazard Ratio
549
The hazard ratio (HR) is a widely used measure in clinical trials to compare the risk of events, such as death or disease recurrence, between two groups over time. It reflects the ratio of hazard rates—the instantaneous risk of the event occurring—between a treatment group and a control group. This measure provides valuable insights into the relative effectiveness of a treatment by assessing how the risk of an event differs between the two groups.
For example, in a clinical trial...
For example, in a clinical trial...
549


