肺密封剂的非标签使用:需要基于证据的指导方针和适当的使用指示
Bob P Hermans1, Wilson W L Li1, Stefan M van der Heide1
1Department of Cardio-thoracic Surgery, Radboud University Medical Center, Nijmegen, The Netherlands.
Journal of thoracic disease
|December 11, 2025
概括
肺密封剂可以帮助控制胸部手术后的空气泄漏,但证据有限. 本次审查强调了非标签使用方面的担忧,并建议为更好的密封剂选择提供实践指南.
科学领域:
- 胸部外科手术 胸部外科手术
- 生物材料是一种生物材料.
- 肺部医学 肺部医学
背景情况:
- 长时间的空气泄漏是胸部手术中常见的并发症,增加了发病率.
- 现有的肺密封剂在有效性方面有异质的证据,只有很少的对比.
- 目前的做法依赖于外科医生的经验,因为缺乏密封剂选择的具体指导方针.
研究的目的:
- 审查目前关于肺部密封剂的证据,以控制空气泄漏.
- 发现证据缺陷,特别是关于非标签密封剂的使用和制造商的角色.
- 为未来的证据生成和实践指南提出建议.
主要方法:
- 对以前测试的肺密封剂进行文献审查.
- 密封剂说明和限制的分析,包括非标签应用.
- 讨论潜在的不良事件和非标签使用的法律影响.
主要成果:
- 几种密封剂,如聚乙烯甘醇喷雾剂和基于白的喷雾剂,经常被非标签使用,特别是对于表面的病变.
- 非标签使用引起了医生对未知的风险和潜在法律问题的担忧.
- 显著缺乏高质量的比较数据和实践指南.
结论:
- 迫切需要通过精心设计的临床试验和网络元分析来产生强有力的证据.
- 制定基于共识的实践指南对于胸部外科医生明智选择密封剂至关重要.
- 解决非标签使用问题和制造商责任对于患者安全至关重要.
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