手术前的肺功能和营养预测了以前经过手术的恶性瘤肺癌患者的生存率
Hiromichi Niikawa1,2,3, Hirotsugu Notsuda1,2, Ken Onodera1,2
1Department of Thoracic Surgery, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan.
Journal of thoracic disease
|December 11, 2025
概括
患有癌症史发展为肺癌的患者面临较差的结果. 低肺功能 (FEV1前%) 和营养状况 (PNI前) 预测这些患者的生存率很低.
科学领域:
- 在瘤学瘤学.
- 肺部病理学 肺部病理学
- 手术瘤学手术瘤学
背景情况:
- 在患有先前恶性瘤的患者中,二次肺癌存在独特的挑战.
- 营养状况下降可能会使这些人的治疗和预后复杂化.
研究的目的:
- 为了确定患有先前恶性瘤病史的患者中原发性肺癌的预后因素.
- 评估肺部和营养状况对生存结果的影响.
主要方法:
- 对528名为原发性肺癌进行完全切除的患者 (2010-2016年) 的回顾性分析.
- 收集的数据包括先前的恶性瘤病史,身体状况,分期和生存结果.
- 统计分析的重点是确定总生存率 (OS) 和无复发生存率 (RFS) 的预测因素.
主要成果:
- 153名患者有先前的恶性病史,呈现出较小的瘤和早期疾病阶段 (pStage 0-IA3).
- 低的手术前百分比预测了1秒内强迫呼吸量 (手术前%FEV1) 和手术前预后营养指数 (手术前PNI) 是早期疾病中不良OS的显著预测因素.
- 患者前%FEV1 < 101.1 和前PNI < 43.1 均显示显著恶化OS和RFS.
结论:
- 尽管较早发现,但患有先前恶性瘤的患者的生存率被肺部和营养状况受损所抵消.
- 前%FEV1和前PNI是这个人群中不良结果的潜在预测因素.
- 为了优化肺部和营养状况的术后干预措施是有必要的,需要未来的验证.
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