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瘤局部免疫调节:对固体恶性瘤的CAR-t细胞工程的关键进展

Maryam Abid1, Ursula Abu Nahla2, Muhammad Nabeel Saddique1

  • 1Department of Radiotherapy and Medical Oncology, King Edward Medical University, Lahore, Pakistan.

Annals of medicine and surgery (2012)
|December 11, 2025
PubMed
概括

有关抗PD-L1和IL-12抗体的工程CAR-T细胞通过局部化治疗和降低毒性来改善固体瘤治疗. 这项创新在临床前模型中增强了抗瘤反应和T细胞透.

关键词:
在CAR-T细胞中.检查点抑制剂检查点抑制剂免疫疗法 免疫疗法固体瘤是一种固体瘤.瘤微环境是一个微环境.

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