认知功能障碍的老年人抑郁症的单一非药物干预:系统性审查和网络元分析
Zhengyi Tan1,2, Baiyun Li1,2, Lanxin Su1,2
1Kiang Wu Nursing College of Macau, Macao, Macao SAR, China.
Frontiers in psychiatry
|December 11, 2025
概括
基于游戏的疗法 (GAME) 和正念是减轻认知功能障碍患者抑郁症状的最有效方法. 这些非药物干预措施与常规护理相比,提供了显著的好处.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 老年学是一门学科.
背景情况:
- 认知功能障碍通常与抑郁症同时发生,影响患者的生活质量.
- 越来越多地探索非药物干预措施来管理这种人群中的抑郁症.
- 现有的文献对各种单一非药理方法的比较疗效存在模两可.
研究的目的:
- 对认知功能障碍患者抑郁症单一非药物干预的疗效进行比较评估.
- 通过网络元分析 (NMA) 来解决当前文献中的模两可.
- 帮助从业者制定最佳的治疗模式来治疗抑郁症.
主要方法:
- 随机对照试验的系统审查和网络元分析 (NMA).
- 在PubMed,Embase,Cochrane和Web of Science数据库中进行的搜索.
- 使用Cochrane手册进行偏见风险评估;由两名调查人员进行独立的数据提取和质量评估.
主要成果:
- 分析了26篇涉及10项单一非药物干预的文章.
- 基于游戏的治疗 (GAME) (SMD = -1.00) 和正念 (SMD = -0.58) 显示出显著的抑郁症症状缓解.
- 基于回忆疗法的护理 (RTBC) (SMD = -0.49),音乐疗法 (MUSIC) (SMD = -0.47) 和体育炼 (PE) (SMD = -0.37) 显示中等到轻微的影响.
结论:
- 游戏和正念成为减轻抑郁症状最有效的独立非药物干预措施.
- RTBC,MUSIC和PE也提供了统计学上显著的好处,尽管在较小程度上.
- 结果很强大,支持GAME和正念为这个患者群体的最佳治疗策略.
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