肠道微生物群在野生的繁殖状态上的纵向变化
Chelsea A Southworth1, Logan Barrios2,3, Mauna R Dasari4
1Department of Biological Sciences, University of Notre Dame, Notre Dame, IN, USA.
bioRxiv : the preprint server for biology
|December 11, 2025
概括
雌性在繁殖过程中表现出显著的肠道微生物变化,怀孕诱导了最明显的变化. 这些微生物变化受到生殖状态和个体宿主因素的影响,影响女性和后代的健康.
科学领域:
- 生殖生物学 生殖生物学
- 微生物组研究的研究.
- 灵长类动物生态学
背景情况:
- 女性生殖过程涉及复杂的生理,荷尔蒙和行为变化.
- 肠道微生物群落被认为影响并受到这些生殖变化的影响.
- 了解生殖过程中的肠道微生物群动态对于母亲和后代的健康至关重要.
研究的目的:
- 描述不同生殖状态的雌性的肠道微生物群的纵向变化.
- 研究肠道微生物组成与生殖生理学 (包括荷尔蒙水平) 之间的关系.
- 确定宿主因素和生殖过渡如何塑造肠道微生物组.
主要方法:
- 16S rRNA基因测序了14年来169只雌性的4,462个便样本.
- 生殖状态的纵向跟踪 (卵巢循环,怀孕,产后缺血症).
- 测量便中的雌激素,孕激素和葡萄糖皮质激素水平.
主要成果:
- 在整个生殖状态中观察到显著的肠道微生物群变化,怀孕显示出不同的模式.
- 从怀孕早期到怀孕中期的过渡期表现出最戏剧性的微生物转变.
- 主体身份是肠道微生物群组成的最强有力的预测因素,特别是在怀孕期间.
- 雌激素和孕激素水平与肠道微生物群有关,但这些关系取决于状态.
结论:
- 肠道微生物群有助于与怀孕相关的生理变化,具有个体特异性的微生物特征.
- 类固醇激素变异会影响肠道微生物群,强调在微生物组研究中需要考虑激素水平.
- 需要进一步研究肠道微生物群在母亲和后代的生殖结果中的作用.
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