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肠道微生物群和心血管健康:机制,治疗潜力和未来方向
Sudeep Edpuganti1, Shravan Subhash1, Sujitha Lekshmi Subrahmaniyan1
1Faculty of Medicine, Tbilisi State Medical University, Tbilisi, Georgia.
Heart international
|December 11, 2025
概括
肠道微生物群通过TMAO和SCFA等代谢物影响心血管疾病 (CVD). 调节肠道微生物组为预防和治疗心血管疾病提供了潜在的新治疗点.
科学领域:
- 微生物组研究的研究.
- 心血管疾病是什么心血管疾病
- 代谢学 代谢学 代谢学
背景情况:
- 肠道微生物组在宿主新陈代谢和免疫功能中起着至关重要的作用.
- 越来越多的证据将肠道失调与心血管疾病 (CVD) 的发展联系在一起.
- 肠心轴是一个复杂的相互作用,影响整体健康.
研究的目的:
- 审查关于肠道和心脏之间的机械联系的文献.
- 探索针对心血管疾病的肠道微生物组的治疗策略.
- 为了确定肠心轴的研究缺口.
主要方法:
- 在PubMed和Embase数据库的系统文献搜索.
- 关键词包括"肠道微生物组"",心血管疾病"",TMAO"",短链脂肪酸"",益生菌"和"便微生物移植".
- 包括关注机制或治疗的人类和动物研究;不包括小案例系列和非英语文章.
主要成果:
- 微生物群的代谢物,如三甲基胺N氧化物 (TMAO) 和短链脂肪酸 (SCFA),影响动脉生成,血压和炎症.
- 肠道屏障功能障碍和改变的胆酸信号传递介于心脏重塑.
- 诸如食纤维,益生菌,益生菌,后生菌和便微生物群移植等干预措施显示出降低心血管疾病风险的潜力.
结论:
- 肠道微生物组调制为预防和治疗心血管疾病提供了一个新的治疗途径.
- 需要进一步的大规模,标准化的随机试验,具有硬心血管终点.
- 综合的多学科分析对验证微生物生物标志物和优化干预措施至关重要.
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