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中国东部型肝炎负担的长期空间时间演变:无锡市的回顾性病例分析
Huan Ding1, Qi Zhang1, Shiya Shen1
1Department of Chronic Infectious Disease Control and Prevention, The Affiliated Wuxi Center for Disease Control and Prevention of Nanjing Medical University, Wuxi Center for Disease Control and Prevention, Wuxi, China.
Frontiers in public health
|December 11, 2025
概括
2007年至2021年,无锡市的C型肝炎病毒 (HCV) 发病率显著增加,特别是在男性和老年人群中. 基因型1b和3是最常见的,病例聚集在城市地区,需要有针对性的控制策略.
科学领域:
- 流行病学 流行病学
- 公共卫生 公共卫生
- 传染性疾病 传染性疾病
背景情况:
- 型肝炎病毒 (HCV) 感染对全球健康造成重大负担.
- 无锡市是中国东部的一个发达地区,在历史上HCV流行率很低,为了了解其流行病学趋势,研究了该地区.
- 研究期从2007年到2021年,涵盖了大量的趋势分析时间框架.
研究的目的:
- 调查无锡市HCV的流行病学特征.
- 分析HCV的时空分布模式.
- 为消除HCV提供有针对性的公共卫生干预信息.
主要方法:
- 来自中国疾病控制和预防信息系统的4771例HCV病例的回顾性分析.
- 使用SPSS进行统计分析,包括时间趋势的结点回归和空间模式的内核密度/热点分析.
- 使用度度和基因型分布的检查量化季节性强度.
主要成果:
- 每10万人口中HCV发病率从2.18上升到9.15 (平均年增长10.50%).
- 男性和老年人患病率较高. 基因型1b (74.5%) 和3 (15.2%) 主导,其中亚型3b占主导地位.
- 病例聚集在城市中心,空间模式随着时间的推移保持相对稳定. 没有发现明显的季节性趋势.
结论:
- 无锡市的HCV发病率显示出令人担忧的上升趋势,由特定的人口统计和基因型驱动.
- 城市地区的空间聚类需要集中预防和控制工作.
- 这些发现强调,需要加强战略,到2030年实现HCV消除.
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