人类乳头瘤病毒 (HPV) 和不孕症:一项跨部门研究,探讨其在伊朗夫妇中的流行率和影响
Nasrin Aliabadi1, Marzieh Hosseini1, Sareh Doustfatemeh2,3
1Department of Clinical Virology, Clinical Microbiology Research Center Shiraz University of Medical Sciences, Namazi Hospital Shiraz Iran.
Health science reports
|December 11, 2025
概括
高风险的人类乳头瘤病毒 (HPV) 感染在16.9%的不孕女性和13%的不孕男性中被检测到,男性高风险类型的患病率更高. 这些发现表明HPV可能导致不孕症,需要进一步调查.
科学领域:
- 生殖医学 生殖医学
- 传染性疾病 传染性疾病
- 妇科 妇科 妇科 妇科
背景情况:
- 不孕症影响全球16%的人口,在伊朗的患病率越来越高.
- 人类乳头瘤病毒 (HPV) 感染是一种常见的性传播感染.
- 需要进一步调查HPV和不孕症之间的关联.
研究的目的:
- 确定伊朗不育夫妇中高风险HPV基因型的流行率.
- 探索HPV感染和不孕不育之间的关系.
主要方法:
- 这是一项涉及354名不育的参与者 (177名女性,177名男性) 年龄在20-45岁之间的横截面研究.
- 实时PCR被用于检测和基因型HPV在精液,宫拭片和子宫吸收.
- 人口,临床和生活方式数据是通过问卷收集的.
主要成果:
- 在女性中,HPV被检测到16.9%,在男性中被检测到13%. 在12.5%的感染女性和40%的感染男性中发现了高风险的HPV类型.
- 感染HPV的女性在结婚时年龄略低.
- 艾滋病病毒阳性个体使用辅助生殖技术减少;艾滋病病毒阳性男性有更高的自雇率和伴侣变化.
结论:
- 这项研究表明,在不育人口中,HPV的发病率适度,与全球研究结果一致.
- HPV 感染可能在生殖功能障碍中起作用,可能会影响精子质量和子宫内膜受容性.
- 建议采取有针对性的查和疫苗接种策略,以减轻与HPV相关的不孕症风险.
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