不同麻醉剂对Remifentanil诱导的输液后过敏症的作用,在经过皮肤内镜间层切除术的患者中:一项随机对照试验
Yanzhe Ba1, Yanan Wang2, Leilei Dai2
1Department of Anesthesiology, Qilu Hospital of Shandong University, Jinan, Shandong, China.
Frontiers in medicine
|December 11, 2025
概括
在手术后,雷米马佐拉姆和普罗波减弱了雷米芬坦尼尔诱导的输液后过敏症 (RPH),改善了患者的舒适度. 塞沃弗兰对RPH没有提供同样的保护作用.
科学领域:
- 麻醉学 麻醉学
- 疼痛管理 疼痛管理
- 药理学 药理学是指药理学的学科.
背景情况:
- 在麻醉期间持续输注雷米芬坦尼尔可以导致雷米芬坦尼尔诱导的输注后过敏症 (RPH).
- 麻醉维持药物可能会影响RPH的发展.
研究的目的:
- 为了研究雷米马佐拉姆,普罗波和塞沃弗对RPH的影响.
- 为了比较不同麻醉剂对术后疼痛和患者满意度的影响.
主要方法:
- 111名接受皮肤内镜间膜切除术 (PEID) 的患者被随机分配给接受雷米马佐拉姆,普罗波或西沃弗以维持麻醉.
- 在手术前和手术后24小时使用弗雷丝丝测量了机械疼痛值.
- 在手术后24小时记录了疼痛强度,sufentanil消耗,副作用,舒适度和满意度.
主要成果:
- 在手术后24小时,雷米马佐拉姆和普罗波群体在切口周围的机械疼痛值明显高于西沃弗兰组.
- 接受雷米马佐拉姆或普罗波的患者报告说,术后舒适度和满意度显著增加.
- 在前臂疼痛值,手术后疼痛强度,sufentanil消耗或小组间的副作用方面没有发现显著差异.
结论:
- 雷米马佐拉姆和普罗波福在PEID后减弱了RPH,但没有影响急性疼痛或止痛药的消耗.
- 这些麻醉剂可以降低手术后患慢性疼痛的风险.
- 与雷米马佐拉姆和普罗波相比,塞沃兰在减轻RPH方面效果较差.
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