来自食物的β-乳球蛋白纳米纤维:一种有效,安全和可扩展的解决方案,以克服口服胰岛素输送的挑战
Xihua Liu1, Shuangjian Li1, Guodong Wu2
1Department of Food Science & Engineering, School of Agriculture & Biology, Shanghai Jiao Tong University, Shanghai, 200240, China.
Bioactive materials
|December 11, 2025
概括
研究人员开发了beta-lactoglobulin (BLG) 纳米纤维,用于口服生物输送. 这些纳米纤维增强了生物可用性并恢复了肠道屏障的完整性,提供了一种可持续的纳米医学方法.
科学领域:
- 生物材料科学 生物材料科学
- 药物运输 药物运输 药物运输
- 纳米技术 纳米技术
背景情况:
- 口服生物制剂在生物可用性和肠道屏障完整性方面面临挑战.
- 目前的解决方案,如化学增强剂或纳米粒子有局限性.
- 需要一种新的方法来克服口服交付三难题.
研究的目的:
- 开发一种使用β-乳糖球蛋白 (BLG) 纳米纤维的生物药物的新型口服输送系统.
- 研究BLG纳米纤维的作用机制,以提高口服生物利用性.
- 评估BLG纳米纤维的安全性和配方灵活性.
主要方法:
- 将β-乳糖球蛋白 (BLG) 转化为纳米纤维.
- 在体内研究,以测量口服胰岛素的生物可用性.
- 评估肠道完整性的长期安全性研究.
- 涉及流入,calpain激活和蛋白酶降解的机制研究.
主要成果:
- BLG纳米纤维实现了口服胰岛素的生物利用率为10.2-12.3%.
- 在长期安全性研究中没有观察到肠道损伤.
- 纳米纤维显示了一个"增强-降解-恢复"机制,涉及calpain激活和蛋白酶降解.
- 纳米纤维素在商业乳制品中保持了辅助活性.
结论:
- BLG纳米纤维提供了一个独特的"增强-降解-恢复"机制,以克服口服生物递送的挑战.
- 这种方法实现了高生物可用性,并确保了胃肠道安全.
- 该研究提出了一个可持续的"废物到纳米医药"战略,具有配方灵活性.
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